Description

L-Isoleucine Thioamide Hydrochloride is a specialized, high-purity derivative of the essential amino acid L-Isoleucine, where the carboxylic acid group is replaced by a thioamide functionality. This modification makes it a valuable chiral building block and intermediate in advanced pharmaceutical research and synthesis. It is particularly critical for medicinal chemists and process development scientists working in the fields of peptidomimetics, protease inhibitor development, and novel therapeutic agent discovery. The compound is supplied as a hydrochloride salt to enhance its stability and solubility for various synthetic applications.

Application

• Pharmaceutical Intermediate: Serves as a key chiral synthon in the synthesis of complex drug candidates, particularly protease inhibitors and other bioactive peptides.
• Peptidomimetics Research: Used to create stable, non-hydrolyzable peptide analogs by incorporating the thioamide bond, which mimics the natural amide linkage.
• Medicinal Chemistry: Employed in structure-activity relationship (SAR) studies to explore new chemical entities for therapeutic applications.
• Biochemical Tool Compound: Acts as a substrate or inhibitor in enzymatic studies to investigate metabolic pathways involving amino acid derivatives.
• Process Development: Utilized in scaling up synthetic routes for active pharmaceutical ingredients (APIs) requiring this specific chiral scaffold.
• Academic & Industrial R&D: Fundamental research in organic synthesis and chemical biology to develop new methodologies and compounds.

Basic Information

Product Name	L-Isoleucine Thioamide Hydrochloride
CAS No.	111013-76-4
Molecular Formula	C6H13N2S•HCl
Molecular Weight	196.71 g/mol
Synonyms	(2S,3S)-2-Amino-3-methylpentanethioamide hydrochloride; L-Isoleucine thioamide HCl; L-Ile-thioamide•HCl; (2S,3S)-3-Methyl-2-(aminothioxomethyl)pentan-1-aminium chloride; Isoleucine thioamide monohydrochloride; (S,S)-Isoleucine thioamide hydrochloride; 2-Amino-3-methylvalerothioamide hydrochloride
EINECS	Contact for details

Quality Control

Our L-Isoleucine Thioamide Hydrochloride is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity for research and development applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. While produced to meet the exacting standards of pharmaceutical R&D, specific compliance with USP, EP, or FCC monographs can be discussed based on project requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Optical Rotation	[α]²⁰D: +30° to +40° (c=1 in H₂O)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.