Description

Enkephalin-Leu, Ala(2)-Cys(6)- CAS NO 110881-59-9 is a synthetic peptide analog of the endogenous opioid peptide enkephalin, featuring specific amino acid substitutions at positions 2 and 6. This modified structure is critical for research into opioid receptor selectivity, peptide stability, and structure-activity relationships (SAR). It serves as a valuable biochemical tool for neuroscientists, pharmacologists, and medicinal chemists engaged in central nervous system (CNS) research and novel therapeutic development.

Application

• Neuroscience Research: Used as a reference standard and active probe in studies of delta (δ) and mu (μ) opioid receptor binding, activation, and signaling pathways.
• Medicinal Chemistry & Drug Discovery: Serves as a key intermediate or template for designing and synthesizing novel peptide-based analgesics with improved metabolic stability and receptor specificity.
• Biochemical Assay Development: Employed in the development and validation of competitive binding assays (e.g., ELISA, RIA) and functional cellular assays to screen for new opioid ligands.
• Pharmacological Studies: Utilized in vitro and in vivo models to investigate the physiological effects of enkephalin analogs on pain perception, mood, and addiction.
• Academic & Institutional Research: A fundamental reagent for universities and research institutes studying neuropeptides, opioid systems, and peptide biochemistry.
• Peptide Conjugation & Labeling: The cysteine residue allows for site-specific conjugation with fluorescent dyes, biotin, or other tags for imaging and detection applications.

Basic Information

Product Name	Enkephalin-Leu, Ala(2)-Cys(6)-
CAS No.	110881-59-9
Molecular Formula	C30H43N7O8S
Molecular Weight	661.77 g/mol
Synonyms	[Leu5]-Enkephalin, [Ala2, Cys6]-; H-Tyr-Ala-Gly-Phe-Leu-Cys-OH; [Ala2, Cys6]-Leu-Enkephalin; L-Alanine-2-L-cysteine-6-leucine-enkephalin; Opioid peptide analog; (5S,8S,11S,14S,17S)-5,17-Bis(2-amino-2-oxoethyl)-8-(4-hydroxybenzyl)-11-(2-methylpropyl)-14-benzyl-2,2-dimethyl-4,7,10,13,16-pentaoxo-3-oxa-6,9,12,15-tetraazaheptadecane-1-sulfonic acid (IUPAC); [Ala2,Cys6]LE
EINECS	Contact for details

Quality Control

Our peptide products are synthesized and purified under strict cGMP-like conditions to ensure batch-to-batch consistency and high purity for research applications. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, consider storing under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Mass spectrum consistent with theoretical molecular weight
Purity (HPLC)	≥ 95% (Area Percent)
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.