Description

(Sar9,Met(O2)11)-Substance P CAS NO 110880-55-2 is a synthetic, oxidized analog of the neuropeptide Substance P, specifically engineered for research applications. This modified peptide is critical for studying the role of methionine sulfoxide in receptor binding, signal transduction, and oxidative stress pathways within neurological and inflammatory research. It is an essential biochemical tool for pharmaceutical R&D, academic institutions, and biotechnology companies focused on neuropharmacology, pain management, and inflammatory disease mechanisms.

Application

• Neuroscience Research: Used as a selective probe to investigate the structure-activity relationship (SAR) of Substance P and its interaction with neurokinin-1 (NK1) receptors.
• Oxidative Stress Studies: Serves as a model compound to examine the biological impact of methionine oxidation on peptide function and stability in cellular environments.
• Pharmacological Assay Development: Employed in high-throughput screening (HTS) and competitive binding assays to discover and characterize new NK1 receptor antagonists.
• Biochemical Standard: Acts as a reference standard in mass spectrometry (MS) and high-performance liquid chromatography (HPLC) for the quantification and validation of Substance P and its metabolites.
• Inflammatory Pathway Analysis: Utilized in cell-based assays to study the modulation of inflammatory responses and cytokine release mediated by oxidized neuropeptides.

Basic Information

Product Name	(Sar9,Met(O2)11)-Substance P
CAS No.	110880-55-2
Molecular Formula	C63H98N18O16S
Molecular Weight	1387.6 g/mol
Synonyms	Substance P (9-sarcosine, 11-methionine sulfoxide); [Sar9, Met(O)11]-Substance P; Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Sar-Leu-Met(O)-NH2; Oxidized Substance P analog; Neurokinin P (oxidized); SP (Sar9, Met(O2)11); Tachykinin, oxidized fragment
EINECS	Contact for details

Quality Control

Every batch of (Sar9,Met(O2)11)-Substance P is manufactured under strict quality management systems and undergoes comprehensive analytical characterization. Our products are tested to ensure high purity and identity, with specifications typically meeting or exceeding standards for research-grade peptides. Certificates of Analysis (COA) detailing purity by HPLC, mass spectrometry (MS) confirmation, and amino acid analysis are provided with each shipment to ensure traceability and reproducibility for your critical research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). For long-term storage, it is recommended to store desiccated at -20°C. Allow the vial to equilibrate to room temperature before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.