Description

Substance P (4-11), β-Ala(4)-Sar(9)-Met(O2)(11)- is a specific, oxidized analog of the Substance P fragment, designed for advanced research into neurokinin receptor signaling and peptide stability. This modified peptide is critical for scientists requiring precise tools to study the structure-activity relationships of tachykinins and their metabolic pathways. It is primarily utilized by researchers in neuroscience, pharmacology, and biochemistry for targeted in vitro and in vivo studies.

Application

• Neuroscience Research: Investigation of Substance P fragment activity and neurokinin-1 (NK1) receptor interactions.
• Pharmacological Studies: Used as a reference standard or active agent in assays studying inflammation, pain transmission, and emesis.
• Peptide Chemistry & Drug Discovery: Serves as a key intermediate or analog for developing stable peptide-based therapeutics and probes.
• Metabolic Pathway Analysis: Studying the effects of methionine sulfoxidation on peptide function and degradation.
• Biochemical Reagent: Employed in cell culture studies and signal transduction research.

Basic Information

Product Name	Substance P (4-11), β-Ala(4)-Sar(9)-Met(O2)(11)-
CAS No.	110863-38-2
Molecular Formula	C44H71N13O13S
Molecular Weight	1014.2 g/mol
Synonyms	Substance P Fragment 4-11, [β-Ala4, Sar9, Met(O)11]-Substance P (4-11); [β-Alanine4, Sarcosine9, Methionine Sulfoxide11]-Substance P (4-11); Arg-Pro-Lys-Pro-β-Ala-Gln-Phe-Sar-Leu-Met(O)-NH2; Neurokinin Peptide Analog; Tachykinin Fragment Analog
EINECS	Contact for details

Quality Control

Every batch of our Substance P (4-11) analog is produced and analyzed under stringent conditions to ensure the highest standards of identity, purity, and consistency for research applications. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing results from advanced chromatographic and spectroscopic methods. Our quality system is designed to meet the exacting requirements of pharmaceutical and life science research.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive); allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Assay (HPLC)	≥ 97%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.