Description

Neurokinin A (4-10), Nle(10)- is a synthetic peptide fragment derived from the endogenous tachykinin, Neurokinin A. This compound is a valuable research tool for studying the structure-activity relationships and biological functions of the Neurokinin A system, particularly its interaction with the NK2 receptor. It is primarily utilized by researchers in the fields of neuroscience, pharmacology, and biochemistry for in vitro and in vivo studies.

Application

• Neuroscience Research: Investigation of tachykinin signaling pathways, neuronal communication, and the role of NK2 receptors in the central and peripheral nervous systems.
• Pharmacological Studies: Used as a reference standard or active agent in assays to screen for and characterize novel NK2 receptor agonists or antagonists.
• Biochemical Research: Study of peptide-receptor interactions, signal transduction mechanisms, and the metabolic pathways of tachykinins.
• Drug Discovery & Development: Serves as a key intermediate or tool compound in the preclinical research phase for disorders related to tachykinin dysregulation.

Basic Information

Product Name	Neurokinin A (4-10), Nle(10)-
CAS No.	110863-33-7
Molecular Formula	C38H62N12O10S
Molecular Weight	854.0 g/mol
Synonyms	NKA(4-10), Nle(10)-; [Nle10]-Neurokinin A (4-10); H-His-Lys-Thr-Asp-Ser-Phe-Nle-NH2; Neurokinin A (4-10) amide, 10-Norleucine-; Norleucine10-Neurokinin A (4-10); NK2 Receptor Agonist Fragment; Tachykinin Fragment
EINECS	Contact for details

Quality Control

Our peptide products are manufactured and analyzed under strict quality management systems. Each batch of Neurokinin A (4-10), Nle(10)- undergoes comprehensive analytical testing, including HPLC for purity and MS for identity confirmation, to ensure it meets the high standards required for research applications. Certificates of Analysis (COA) with detailed chromatographic data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 8.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.