Description

Boc-D-Homoarg(Et)2-Oh is a protected, non-natural amino acid derivative featuring a homoarginine backbone with ethyl ester groups and a tert-butoxycarbonyl (Boc) protecting group. This compound is a critical building block in advanced peptide synthesis, enabling the introduction of modified arginine analogs with enhanced stability and specific functional properties. It is primarily utilized by pharmaceutical researchers and fine chemical manufacturers developing novel therapeutic peptides, protease inhibitors, and biochemical tools.

Application

• Pharmaceutical Intermediate: Key synthon for the solid-phase and solution-phase synthesis of novel peptide-based drug candidates.
• Protease Inhibitor Development: Used to create analogs that mimic arginine for targeting trypsin-like serine proteases in drug discovery.
• Biochemical Research: Serves as a specialized building block for studying enzyme-substrate interactions and signal transduction pathways.
• Peptidomimetics: Integral for constructing conformationally constrained peptides with improved metabolic stability and bioavailability.
• API (Active Pharmaceutical Ingredient) Synthesis: Employed in the multi-step synthesis of complex active ingredients for preclinical and clinical development.

Basic Information

Product Name	Boc-D-Homoarg(Et)2-Oh
CAS No.	110761-76-7
Molecular Formula	C₁₉H₃₇N₅O₆
Molecular Weight	431.53 g/mol
Synonyms	Boc-D-homoarginine(OEt)2-OH; (2R)-5-[(Diaminomethylidene)amino]-2-[(2-methylpropan-2-yl)oxycarbonylamino]-N,N-diethylpentanamide; N-α-Boc-N-ω,ω'-diethyl-D-homoarginine; tert-Butyloxycarbonyl-D-homoarginine diethyl ester; Boc-D-HArg(OEt)2-OH; N-(tert-Butoxycarbonyl)-D-homoarginine diethylamide; D-Homoarginine derivative, Boc-protected
EINECS	Contact for details

Quality Control

Every batch of Boc-D-Homoarg(Et)2-Oh is manufactured under strict quality management systems. Our products undergo rigorous analytical testing, including HPLC, NMR, and mass spectrometry, to ensure high chemical purity and chiral integrity, meeting the exacting standards required for pharmaceutical research. Certificates of Analysis (COA) with full traceability are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent decomposition. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (D-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.