Description

3-Mercaptopropionyl-Phe-D-Ala-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-Nh2 is a synthetic peptide featuring a thiol-containing mercaptopropionyl group at its N-terminus. This compound is of significant interest in advanced biochemical research and pharmaceutical development due to its specific sequence and reactive thiol functionality, which enables site-specific conjugation and labeling. It is primarily utilized by research institutions and biopharmaceutical companies engaged in peptide-based drug discovery, proteomics, and the development of targeted therapeutic agents.

Application

• Bioconjugation and Protein Labeling: The reactive thiol group serves as a key handle for site-specific conjugation to maleimide or iodoacetyl-functionalized molecules, such as fluorophores, biotin, or drug payloads.
• Pharmaceutical Research & Development: Used as a key intermediate or model compound in the discovery and development of novel peptide-based therapeutics, including targeted cancer therapies.
• Protease Substrate Studies: Employed as a specific substrate to study the activity and inhibition of proteolytic enzymes relevant to disease pathways.
• Biomarker Discovery and Assay Development: Functions as a critical component in the development of sensitive immunoassays or diagnostic tests.
• Structural Biology and Peptide Mapping: Used in studies to understand protein-protein interactions and for mass spectrometry-based peptide analysis.
• Antigen Synthesis: Can be utilized for the generation of antibodies against specific peptide epitopes for research and diagnostic purposes.

Basic Information

Product Name	3-Mercaptopropionyl-Phe-D-Ala-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-Nh2
CAS No.	110326-94-8
Molecular Formula	C112H178N34O30S2
Molecular Weight	2476.9 g/mol (theoretical)
Synonyms	MPP-FDAGRIDRIGAQSGLGCN-SFRY-NH2; 3-Mercaptopropionyl-Phe-D-Ala-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-amide; Thiol-Peptide Conjugate; S-(2-Carboxyethyl)-Cys1-peptide; Custom Peptide 110326-94-8; Mercaptopropionyl Modified Peptide; Research Peptide with Free Thiol
EINECS	Contact for details

Quality Control

Our high-purity peptides are manufactured under strict quality management systems. Each batch of 3-Mercaptopropionyl-Phe-D-Ala-Gly-Arg-Ile-Asp-Arg-Ile-Gly-Ala-Gln-Ser-Gly-Leu-Gly-Cys-Asn-Ser-Phe-Arg-Tyr-Nh2 undergoes comprehensive analytical testing, including HPLC for purity assessment and MS for identity confirmation, to ensure it meets exacting research-grade specifications. A detailed Certificate of Analysis (COA) providing batch-specific data is supplied with every order.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive) and easily oxidized; it is recommended to store under an inert atmosphere such as argon or nitrogen after opening. Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.