Description

H-D-Phg-Leu-Oh is a high-purity, non-natural dipeptide building block used in advanced pharmaceutical research and development. This compound is critical for the synthesis of complex peptide-based drug candidates, enabling the exploration of novel therapeutic mechanisms. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and fine chemical sectors for applications in drug discovery and process development.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel peptide-based active pharmaceutical ingredients (APIs).
• Drug Discovery Research: Used in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization.
• Peptide Library Synthesis: Essential for creating combinatorial libraries in high-throughput screening for new drug candidates.
• Bioconjugation: Serves as a linker or spacer molecule in the development of antibody-drug conjugates (ADCs) and other bioconjugates.
• Biochemical Research: Employed as a substrate or inhibitor in enzymatic studies and proteomics research.
• Fine Chemical Synthesis: Used as a chiral synthon in the asymmetric synthesis of complex organic molecules.

Basic Information

Product Name	H-D-Phg-Leu-Oh
CAS No.	110207-44-8
Molecular Formula	C15H22N2O3
Molecular Weight	278.35 g/mol
Synonyms	H-D-Phenylglycyl-L-leucine; D-Phenylglycyl-L-leucine; (R)-2-((S)-2-Amino-4-methylpentanamido)-2-phenylacetic acid; H-D-Phg-L-Leu-OH; D-Phegly-L-Leu; Boc-D-Phg-Leu-OH (precursor); Fmoc-D-Phg-Leu-OH (precursor); D-Phenylglycine-L-leucine dipeptide
EINECS	Contact for details

Quality Control

Our H-D-Phg-Leu-Oh is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity, suitable for research and cGMP applications. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant ICH guidelines and can supply material that meets stringent in-house specifications for chiral purity and chemical stability.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% de
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.