Description

5-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci) is a highly reactive and versatile heterocyclic acid chloride building block. This compound is critical for the synthesis of complex pyrimidine derivatives, enabling the introduction of the 5-carboxamide or 5-ester functionality. It is primarily sought after by research chemists and process development scientists in the pharmaceutical and agrochemical industries for constructing active pharmaceutical ingredients (APIs) and advanced intermediates.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of nucleoside analogs, kinase inhibitors, and other small molecule therapeutics targeting various disease pathways.
• Agrochemical Synthesis: Used in the research and development of novel herbicides, fungicides, and plant growth regulators containing the pyrimidine core.
• Material Science Research: Serves as a precursor for creating functionalized polymers, ligands for metal-organic frameworks (MOFs), and other advanced materials.
• Chemical Biology & Proteomics: Employed in the design and synthesis of activity-based probes, affinity tags, and other tools for studying biological systems.
• Custom Synthesis & Contract Manufacturing: A vital starting material for custom synthesis houses and CDMOs (Contract Development and Manufacturing Organizations) producing specialized compounds for clients.

Basic Information

Product Name	5-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci)
CAS No.	110099-99-5
Molecular Formula	C5H2Cl2N2O
Molecular Weight	176.99 g/mol
Synonyms	2-Chloropyrimidine-5-carbonyl chloride; 2-Chloro-5-pyrimidinecarbonyl chloride; 2-Chloropyrimidine-5-carboxylic acid chloride; 5-(Chlorocarbonyl)-2-chloropyrimidine; 2-Chloro-5-(chlorocarbonyl)pyrimidine; 2-Chloropyrimidine-5-carbonyl Chloride; 2-Chloro-5-pyrimidinecarboxylic acid chloride
EINECS	Contact for details

Quality Control

Every batch of 5-Pyrimidinecarbonyl Chloride, 2-Chloro- (9Ci) is produced and tested under strict quality management protocols to ensure consistency and reliability for your synthetic workflows. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing key parameters such as purity (by HPLC/NMR), identity confirmation, and impurity profiles. Our commitment to GMP-compliant practices in handling high-value intermediates ensures material integrity from production to delivery.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic and moisture-sensitive nature, the container must be kept tightly sealed under an inert atmosphere (e.g., nitrogen or argon) after opening to prevent decomposition. Keep away from heat, open flames, and incompatible materials such as strong bases, alcohols, and water.

Specification

Item	Specification
Appearance	White to off-white crystalline powder or solid
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Purity (HPLC)	≥ 97.0% (Area %)
Water Content (KF)	≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.