Description

(S)-Lorazepam is the single enantiomer of the well-established benzodiazepine derivative, lorazepam. This high-purity chiral intermediate is critical for pharmaceutical research and development, particularly in the synthesis of enantiomerically pure active pharmaceutical ingredients (APIs). It is essential for manufacturers and research institutions focused on developing novel neuropharmacological agents, chiral switches, and advanced drug delivery systems where stereochemical purity directly impacts therapeutic efficacy and safety profiles.

Application

• Pharmaceutical Intermediate: Key chiral building block for the synthesis of enantiopure benzodiazepine-based active pharmaceutical ingredients (APIs).
• Neurological Research: Used in preclinical and clinical research to study the stereospecific mechanisms of action on GABA-A receptors.
• Reference Standard: Serves as a high-purity chemical reference standard (CRS) for analytical method development and quality control in pharmaceutical laboratories.
• Chiral Synthesis: Employed in asymmetric synthesis and process chemistry for creating novel compounds with targeted neurological activity.
• Metabolite Studies: Utilized in the research and synthesis of specific drug metabolites for pharmacokinetic and toxicological profiling.

Basic Information

Product Name	(S)-Lorazepam
CAS No.	110032-65-0
Molecular Formula	C15H10Cl2N2O2
Molecular Weight	321.16 g/mol
Synonyms	(S)-7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one; (S)-Lorazepam; (-)-Lorazepam; Levonordazepam; (S)-Enantiomer of Lorazepam; UNII-5O8U4C2F3K; Lorazepam S-(-)-enantiomer
EINECS	Contact for details

Quality Control

Our (S)-Lorazepam is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including chiral purity determination by HPLC, to ensure it meets the stringent requirements for pharmaceutical research and development. Certificates of Analysis (COA) detailing identity, purity, and enantiomeric excess are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Enantiomeric Purity (Chiral HPLC)	≥99.0%
Loss on Drying	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.