Description

Hirudin (54-65) (Sulfated) is a specific, sulfated fragment of the potent natural thrombin inhibitor, hirudin. This synthetic peptide is critical for advanced biochemical research and development due to its high-affinity, selective binding to thrombin. It is primarily utilized by pharmaceutical R&D teams, diagnostic manufacturers, and academic researchers focused on hemostasis, thrombosis, and cardiovascular disease mechanisms. The compound offers a well-defined tool for studying thrombin's role in coagulation cascades and developing novel antithrombotic agents.

Application

• Biochemical Research: As a high-purity reference standard for studying thrombin inhibition kinetics and structure-activity relationships (SAR).
• Pharmaceutical Development: A key intermediate or pharmacophore model in the design and screening of new anticoagulant and antithrombotic drug candidates.
• Diagnostic Assays: Used in the development and calibration of in vitro diagnostic tests for coagulation disorders and monitoring anticoagulant therapies.
• Enzyme Studies: Serves as a specific active-site inhibitor in proteomic and enzymatic studies to elucidate thrombin's functions beyond coagulation.
• Academic & Clinical Research: Fundamental tool for investigating pathways of hemostasis, thrombosis, inflammation, and cell signaling in cardiovascular diseases.

Basic Information

Product Name	Hirudin (54-65) (Sulfated)
CAS No.	109528-49-6
Molecular Formula	C60H91N19O28S3
Molecular Weight	1594.7 g/mol
Synonyms	Hirudin Fragment 54-65 (sulfated); [Tyr(SO3H)63]-Hirudin (54-65); Hirudin (54-65), Tyr(SO3)-63-; Sulfated Hirudin Peptide (54-65); Thrombin Inhibitor Peptide (sulfated); H-Gly-Asp-Phe-Glu-Glu-Ile-Pro-Glu-Glu-Tyr(SO3H)-Leu-Gln-OH; Hirudin C-terminal fragment (sulfated).
EINECS	Contact for details

Quality Control

Our Hirudin (54-65) (Sulfated) is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and peptide content. We adhere to relevant guidelines for peptide synthesis and can provide material traceable to primary reference standards upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content (UV)	≥ 80%
Single Impurity (HPLC)	≤ 1.0%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Solubility	Soluble in water or buffer

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.