Description

Pyr-Gln-Oh CAS NO 109481-23-4 is a high-purity, protected amino acid derivative, specifically pyroglutamyl-glutamine. This compound serves as a critical building block in advanced peptide synthesis, offering precise control over molecular structure and function. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key raw material for the synthesis of complex peptide-based drugs and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected glutamine residue to prevent side reactions.
• Biochemical Research: Serves as a standard or reagent in metabolic pathway studies, enzyme substrate research, and proteomics.
• Cosmetic Peptides: A potential ingredient in the development of advanced anti-aging and skin-repair cosmetic peptides.
• Diagnostic Development: Can be utilized in creating labeled peptides for diagnostic assays and imaging probes.

Basic Information

Item	Details
Product Name	Pyr-Gln-Oh
CAS No.	109481-23-4
Molecular Formula	C10H15N3O5
Molecular Weight	257.24 g/mol
Synonyms	L-Pyroglutamyl-L-glutamine; Pyr-Gln-OH; 5-Oxo-L-prolyl-L-glutamine; 5-Oxoprolylglutamine; L-Glutamine, L-5-oxoprolyl-; (S)-2-((S)-5-Oxopyrrolidine-2-carboxamido)pentanediamic acid; pGlu-Gln-OH; N-(L-5-Oxopyrrolidin-2-carbonyl)-L-glutamine
EINECS	Contact for details

Quality Control

Every batch of Pyr-Gln-Oh is manufactured under strict quality management systems. We provide comprehensive quality assurance with testing that typically includes identification, purity assay, and impurity profiling via advanced analytical techniques like HPLC and NMR. Certificates of Analysis (COA) are available for all shipments, detailing batch-specific results and confirming compliance with agreed specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm
Residue on Ignition	≤0.5%
Single Impurity (HPLC)	≤1.0%
Total Impurities (HPLC)	≤2.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.