Description

(9H-Fluoren-9-Yl)Methoxy]Carbonyl Ile-Pro-Oh is a protected dipeptide building block, specifically an Fmoc-protected isoleucyl-proline derivative. This compound is essential for the solid-phase peptide synthesis (SPPS) of complex peptides and peptidomimetics, offering precise control over the amino acid sequence. It is a critical raw material for researchers and manufacturers in pharmaceutical development, particularly for creating therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): As an Fmoc-protected amino acid derivative, it serves as a key building block for the sequential assembly of custom peptides.
• Pharmaceutical R&D: Used in the research and development of novel peptide-based drugs targeting metabolic disorders, cardiovascular diseases, and oncology.
• Bioconjugation: Employed to create peptide tags or linkers for conjugating drugs to antibodies, polymers, or other biomolecules (e.g., Antibody-Drug Conjugates - ADCs).
• Protease Substrate Synthesis: The Ile-Pro sequence is of interest in synthesizing substrates for studying protease enzyme activity and inhibition.
• Combinatorial Chemistry: A valuable component in libraries for high-throughput screening to discover new bioactive compounds.
• Biochemical Research: Used as a standard or reagent in studies of protein folding, enzyme kinetics, and molecular recognition.

Basic Information

Product Name	(9H-Fluoren-9-Yl)Methoxy]Carbonyl Ile-Pro-Oh
CAS No.	109425-47-0
Molecular Formula	C25H28N2O5
Molecular Weight	436.50 g/mol
Synonyms	Fmoc-Ile-Pro-OH; Fmoc-L-Isoleucyl-L-proline; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-isoleucyl-L-proline; (9-Fluorenylmethoxycarbonyl)isoleucylproline; Fmoc-Ile-Pro; Nα-Fmoc-L-isoleucyl-L-proline; N-Fmoc-isoleucyl-proline; L-Isoleucyl-L-proline, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-
EINECS	Contact for details

Quality Control

Our (9H-Fluoren-9-Yl)Methoxy]Carbonyl Ile-Pro-Oh is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation by NMR and mass spectrometry. We provide comprehensive Certificates of Analysis (COA) detailing all specifications to ensure compliance with research and cGMP-grade requirements for pharmaceutical applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C (refrigerated) or as specified on the label or COA. This product is hygroscopic (moisture-sensitive); ensure the container is sealed tightly after each use to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.