Description

Glucagon, Des-His(1)-Tyr(22)- (CAS NO 109376-06-9) is a synthetic peptide analog of glucagon, a key hormone involved in glucose metabolism. This modified sequence is of significant value for advanced biochemical research and pharmaceutical development, particularly in studying receptor-ligand interactions and metabolic pathways. It is primarily needed by research institutions, biotechnology companies, and pharmaceutical developers focused on endocrinology, diabetes research, and peptide-based therapeutic discovery.

Application

• Biochemical Research: Used as a critical tool for studying the structure-activity relationship (SAR) of glucagon and its receptor binding mechanisms.
• Pharmaceutical Development: Serves as a reference standard or intermediate in the development of novel peptide therapeutics targeting metabolic disorders.
• Endocrinology Studies: Employed in in vitro and ex vivo assays to investigate glucose homeostasis and hormonal regulation.
• Receptor Binding Assays: Utilized in competitive binding studies to characterize and screen for glucagon receptor (GCGR) agonists or antagonists.
• Academic Research: A key reagent for university and institutional labs exploring peptide chemistry and hormone signaling pathways.

Basic Information

Product Name	Glucagon, Des-His(1)-Tyr(22)-
CAS No.	109376-06-9
Molecular Formula	C152H225N43O48S
Molecular Weight	~3408.8 g/mol
Synonyms	Des-His(1)-Tyr(22)-Glucagon; [Tyr22]Glucagon (1-29), Des-His1-; Glucagon (2-29), Tyr22-; Glucagon fragment 2-29, Tyr22-; H-Ser-Gln-Gly-Thr-Phe-Thr-Ser-Asp-Tyr-Ser-Lys-Tyr-Leu-Asp-Ser-Arg-Arg-Ala-Gln-Asp-Phe-Tyr-Gln-Leu-Met-Asn-Thr-OH; GCGR Ligand Analog; Glucagon Analog
EINECS	Contact for details

Quality Control

Our Glucagon, Des-His(1)-Tyr(22)- is produced under stringent conditions to ensure high purity and batch-to-batch consistency, suitable for sensitive research applications. Each batch is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to rigorous internal quality standards and can provide material tailored to specific research-grade requirements upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to reach room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.