Description

(D-Arg0,Hyp3,D-Phe7)-Bradykinin is a synthetic, modified peptide analog of the endogenous vasoactive nonapeptide bradykinin, designed with specific D-amino acid substitutions to enhance its metabolic stability and receptor selectivity. This engineered compound is crucial for advanced pharmacological research, particularly in studying the complex signaling pathways of the kinin-kallikrein system and for the development of novel therapeutic agents. It serves as an essential tool for researchers and developers in pharmaceutical R&D, academic biochemistry, and preclinical studies focusing on inflammation, pain, cardiovascular function, and central nervous system disorders.

Application

• Pharmacological Research: Used as a stable, receptor-selective probe to investigate bradykinin B1 and B2 receptor mechanisms, signal transduction, and downstream effects.
• Drug Discovery & Development: Serves as a key reference standard and lead compound in the design of new peptide-based therapeutics targeting inflammatory and cardiovascular diseases.
• Biochemical Assays: Employed in in vitro and cell-based assays to study peptide-receptor interactions, potency, and metabolic stability.
• Academic & Institutional Studies: Fundamental tool for university and research institute labs exploring the physiological and pathophysiological roles of the kinin system.
• Analytical Standard: High-purity grade material is used for method development, calibration, and quality control in analytical laboratories (HPLC, MS).

Basic Information

Product Name	(D-Arg0,Hyp3,D-Phe7)-Bradykinin
CAS No.	109333-26-8
Molecular Formula	C50H73N15O11
Molecular Weight	1052.2 g/mol
Synonyms	D-Arg-Arg-Pro-Hyp-Gly-Phe-D-Phe-Leu-Arg; D-Arg0-Hyp3-D-Phe7-Bradykinin; [D-Arg0, Hyp3, D-Phe7]-BK; Bradykinin, 1-D-arginine-4-hydroxyproline-7-D-phenylalanine-; Modified Bradykinin Fragment; BK B1/B2 Receptor Ligand; Synthetic Bradykinin Analog; H-D-Arg-Arg-Pro-Hyp-Gly-Phe-D-Phe-Leu-Arg-OH
EINECS	Contact for details

Quality Control

Our (D-Arg0,Hyp3,D-Phe7)-Bradykinin is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity for research applications. Each lot is supported by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles. We adhere to relevant industry standards for peptide synthesis and can provide material tailored to specific project requirements, including research-grade and analytical reference standard grades.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95%
Assay (Peptide Content)	≥ 80%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.