Description

5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-4(3H)-One(Hcl Salt) is a high-purity heterocyclic building block and pharmaceutical intermediate of significant commercial interest. Its value lies in its role as a critical synthon for the research and development of novel active pharmaceutical ingredients (APIs), particularly in therapeutic areas requiring complex nitrogen-containing scaffolds. This compound is essential for medicinal chemists and process development scientists in the pharmaceutical, biotechnology, and fine chemical industries.

Application

• Pharmaceutical Intermediate: Serves as a key precursor in the synthesis of potential drug candidates targeting various diseases.
• Medicinal Chemistry Research: Used as a versatile building block for constructing complex molecular libraries in drug discovery programs.
• API Development: Integral to the process research and scale-up of new active pharmaceutical ingredients, especially kinase inhibitors and other targeted therapies.
• Biochemical Research: Employed in the study of enzyme-substrate interactions and biological pathways due to its privileged pyrimidine-based structure.
• Fine Chemical Synthesis: Utilized in the multi-step synthesis of specialty chemicals and advanced materials requiring specific heterocyclic motifs.

Basic Information

Product Name	5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-4(3H)-One(Hcl Salt)
CAS No.	109229-08-5
Molecular Formula	C7H10N3O·HCl
Molecular Weight	189.63 g/mol (Free base: 152.18 g/mol)
Synonyms	5,6,7,8-Tetrahydropyrido[4,3-d]pyrimidin-4(3H)-one hydrochloride; 3,4,6,7-Tetrahydro-4-oxopyrido[4,3-d]pyrimidine hydrochloride; 4(3H)-Pyrimidinone, 5,6,7,8-tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one, hydrochloride; 5,6,7,8-Tetrahydro-3H-pyrido[4,3-d]pyrimidin-4-one hydrochloride; THPP-HCl; Pyrido[4,3-d]pyrimidin-4(3H)-one, 5,6,7,8-tetrahydro-, hydrochloride
EINECS	Contact for details

Quality Control

Our 5,6,7,8-Tetrahydropyrido[4,3-D]Pyrimidin-4(3H)-One(Hcl Salt) is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for pharmaceutical R&D and production. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0%; Any single impurity ≤ 1.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.