Description

Boc-L-Cyclopentylglycine is a protected, non-proteinogenic amino acid derivative widely used as a key chiral building block in organic synthesis. This high-purity intermediate is critical for introducing the constrained cyclopentylglycine moiety into peptide chains and other complex molecules, enabling the development of compounds with enhanced metabolic stability and binding affinity. It is essential for research and production in the pharmaceutical industry, particularly in the development of novel therapeutics, peptide mimetics, and active pharmaceutical ingredients (APIs).

Application

• Pharmaceutical Intermediate: A crucial chiral synthon for the synthesis of novel drug candidates and Active Pharmaceutical Ingredients (APIs).
• Peptide Chemistry: Used in Solid-Phase Peptide Synthesis (SPPS) and solution-phase synthesis to incorporate the constrained cyclopentylglycine residue into peptide sequences.
• Protease Inhibitor Development: Serves as a building block for creating inhibitors targeting various proteases, including HCV NS3/4A and others.
• Chemical Biology & Drug Discovery: Employed in medicinal chemistry for structure-activity relationship (SAR) studies and lead optimization to improve pharmacokinetic properties.
• Bioconjugation & Linker Chemistry: Utilized in the design of peptide-drug conjugates (PDCs) and other bioconjugates due to its reactive carboxylic acid and protected amine functionalities.
• Academic & Industrial R&D: A valuable reagent for research laboratories and CROs (Contract Research Organizations) exploring new chemical entities and bioactive peptides.

Basic Information

Product Name	Boc-L-Cyclopentylglycine
CAS No.	109183-72-4
Molecular Formula	C₁₂H₂₁NO₄
Molecular Weight	243.30 g/mol
Synonyms	(S)-2-((tert-Butoxycarbonyl)amino)-2-cyclopentylacetic acid; N-(tert-Butoxycarbonyl)-L-cyclopentylglycine; Boc-Cpg-OH; Boc-L-2-Amino-2-cyclopentylacetic acid; N-Boc-L-cyclopentylglycine; (S)-2-(tert-Butoxycarbonylamino)-2-cyclopentylacetic acid; tert-Butyloxycarbonyl-L-cyclopentylglycine; L-Cyclopentylglycine, N-Boc-
EINECS	Contact for details

Quality Control

Our Boc-L-Cyclopentylglycine is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm enantiomeric excess, and identity confirmation via IR and NMR spectroscopy. We provide full traceability and Certificates of Analysis (COA) are available for every shipment, ensuring compliance with the stringent requirements of pharmaceutical and research applications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (NMR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0% ee
Water Content (KF)	≤0.5%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.