Description

L-Histidine, 3-(Phenylmethyl)-, Dihydrochloride is a modified amino acid derivative, specifically a benzyl-protected histidine salt. This compound is valued for its role as a key chiral building block and intermediate in sophisticated organic synthesis, particularly in pharmaceutical research and development. It is essential for chemists and manufacturers in the life sciences sector who require high-purity, specialized intermediates for producing peptides, active pharmaceutical ingredients (APIs), and other bioactive molecules.

Application

• Pharmaceutical Intermediate: A critical chiral synthon for the research and synthesis of novel peptide-based drugs and therapeutic compounds.
• Peptide Chemistry: Used in solid-phase and solution-phase peptide synthesis (SPPS) as a protected histidine derivative to prevent side reactions.
• Biochemical Research: Serves as a standard or reagent in enzymatic studies and metabolic pathway investigations involving histidine pathways.
• API Development: Employed in the development and scale-up processes for new active pharmaceutical ingredients requiring modified amino acid structures.
• Asymmetric Synthesis: Utilized as a building block in catalytic asymmetric synthesis to introduce chirality into complex molecular architectures.
• Protecting Group Strategy: The benzyl group on the imidazole ring allows for selective deprotection in multi-step synthetic sequences.

Basic Information

Product Name	L-Histidine, 3-(Phenylmethyl)-, Dihydrochloride
CAS No.	109013-61-8
Molecular Formula	C13H19N3O2 · 2HCl
Molecular Weight	338.23 g/mol
Synonyms	L-Histidine, N(pi)-benzyl-, dihydrochloride; (S)-2-Amino-3-(1-benzyl-1H-imidazol-4-yl)propanoic acid dihydrochloride; N(π)-Benzyl-L-histidine dihydrochloride; 1-Benzyl-L-histidine dihydrochloride; Histidine(Bzl)-OH · 2HCl; Boc-His(Bzl)-OH · 2HCl (when referring to Boc-protected precursor); Fmoc-His(Bzl)-OH · 2HCl (when referring to Fmoc-protected precursor); Protected L-Histidine dihydrochloride salt
EINECS	Contact for details

Quality Control

Our L-Histidine, 3-(Phenylmethyl)-, Dihydrochloride is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), chiral purity, and residual solvent levels is provided with every shipment to guarantee traceability and compliance.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and handling properties.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.