Description

Pre-Proparathyroid Hormone (29+1) Amide, Tyr(1)-Ala(14)-Nle(18,21,25)- is a synthetic peptide analog of parathyroid hormone (PTH), engineered for enhanced stability and research utility. This compound is a critical tool for investigating calcium and phosphate metabolism, bone biology, and the molecular mechanisms of PTH receptor activation. It is primarily utilized by pharmaceutical R&D teams, academic research institutions, and biotechnology companies focused on metabolic disorders and osteoporosis therapeutics.

Application

• Biomedical Research: Fundamental studies on parathyroid hormone (PTH) signaling pathways, receptor binding affinity, and downstream cellular effects.
• Drug Discovery & Development: Serving as a reference standard or active pharmaceutical ingredient (API) intermediate in the development of novel anabolic agents for osteoporosis and other bone diseases.
• In Vitro & In Vivo Assays: Used in cell-based assays and animal models to study calcium homeostasis, bone formation, and renal phosphate handling.
• Receptor Characterization: Critical for mapping the interaction between PTH and its G-protein coupled receptor (PTH1R) to understand structure-activity relationships.
• Metabolic Disorder Studies: Research into conditions such as hyperparathyroidism, hypoparathyroidism, and chronic kidney disease-mineral and bone disorder (CKD-MBD).
• Quality Control & Analytical Standards: Employed as a high-purity calibrant or standard in HPLC, LC-MS, and other analytical methods for peptide quantification and identification.

Basic Information

Product Name	Pre-Proparathyroid Hormone (29+1) Amide, Tyr(1)-Ala(14)-Nle(18,21,25)-
CAS No.	108998-59-0
Molecular Formula	C181H291N55O51
Molecular Weight	4088.6 g/mol (theoretical)
Synonyms	PTH (1-34) amide, [Tyr1, Ala14, Nle18,21,25]-; [Tyr1, Ala14, Nle18,21,25]Parathyroid Hormone (1-34) amide; Human PTH (1-34) amide analog; Nle18,21,25, Tyr1, Ala14 PTH(1-34)NH2; Parathyroid Hormone Fragment 1-34 amide (modified); hPTH(1-34)NH2 analog; PreProPTH (29+1) amide derivative; Synthetic PTH analog for research.
EINECS	Contact for details

Quality Control

Our synthetic peptide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical characterization to ensure identity, purity, and consistency. Certificates of Analysis (COA) are provided, detailing results from HPLC, MS, and amino acid analysis. We support research and development requiring materials produced with GMP-like controls for reliable and reproducible experimental outcomes.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dedicated freezer. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake. For long-term storage, consider under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Retention time corresponds to reference standard
Identification (MS)	Molecular weight confirmed by mass spectrometry
Purity (HPLC)	≥ 95.0%
Assay (Peptide Content)	≥ 80.0% (by amino acid analysis)
Single Impurity (HPLC)	≤ 2.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.