Description

Ac-Phe-3-Thiaphe-Oh* is a specialized, non-natural amino acid derivative featuring a thiophene side chain. This compound is of significant interest in advanced pharmaceutical research and development, particularly for the synthesis of novel peptide-based therapeutics and bioactive molecules. It serves as a critical building block for medicinal chemists and researchers in the biotechnology sector, enabling the exploration of new chemical spaces and the modulation of peptide properties. Its unique structure makes it valuable for applications in drug discovery, proteomics, and the development of diagnostic agents.

Application

• Pharmaceutical Intermediate: A key building block for the synthesis of novel peptide drugs and therapeutic candidates.
• Medicinal Chemistry Research: Used in structure-activity relationship (SAR) studies to develop new bioactive compounds with modified properties.
• Peptide Synthesis: Incorporated into custom peptides to introduce the unique thiophene moiety, altering solubility, stability, and receptor binding.
• Bioconjugation: Serves as a handle for linking peptides to other molecules, such as fluorophores or drug payloads, in bioconjugate development.
• Proteomics & Biochemical Tools: Utilized in the design of enzyme inhibitors, substrates, or probes for studying biological pathways.
• Academic & Industrial R&D: Fundamental research material in universities and corporate labs for exploring new chemical entities.

Basic Information

Product Name	Ac-Phe-3-Thiaphe-Oh*
CAS No.	108906-59-8
Molecular Formula	C₁₆H₁₅NO₃S
Molecular Weight	301.36 g/mol
Synonyms	Acetylphenylalanyl-3-thienylalanine; N-Acetyl-3-(2-thienyl)-L-alanyl-L-phenylalanine; Ac-Phe-(3-Thienyl-Ala)-OH; N-Acetyl-L-phenylalanyl-3-(2-thienyl)-L-alanine; Fmoc-Phe(3-Thia)-OH (precursor related); Protected dipeptide analog; Thiophene-containing amino acid derivative; Non-proteinogenic amino acid derivative
EINECS	Contact for details

Quality Control

Our Ac-Phe-3-Thiaphe-Oh* is produced under strict quality management protocols. Each batch undergoes comprehensive analytical testing, including HPLC for purity, NMR and MS for structural confirmation, and chiral analysis to ensure enantiomeric integrity. We provide full traceability and Certificates of Analysis (COA) are available for all shipments, detailing purity, identity, and impurity profiles to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (MS)	Conforms
Purity (HPLC)	≥ 97.0%
Water Content (KF)	≤ 1.0%
Specific Rotation	Contact for details
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.