Description

H-Ala-Glu(Otbu)-Nh2 Hcl is a protected dipeptide building block, specifically an alanine-glutamate derivative with a tert-butyl ester protecting group on the glutamate side chain and an amide C-terminus. This compound is a critical intermediate in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, offering precise control over sequence and structure. It is primarily utilized by pharmaceutical R&D departments, biotechnology firms, and fine chemical manufacturers engaged in developing therapeutic peptides, diagnostic agents, and biochemical research tools.

Application

• Pharmaceutical Intermediate: Key building block for the synthesis of novel therapeutic peptides targeting metabolic disorders, oncology, and neurological conditions.
• Bioconjugation & Probe Development: Used in the creation of labeled peptides for diagnostic imaging, fluorescence studies, and target identification.
• Peptidomimetic Research: Serves as a precursor for designing and synthesizing stable peptide analogs with enhanced bioavailability and metabolic stability.
• Biochemical Reagent: Employed in enzymatic studies and as a substrate or inhibitor in protease and peptidase research.
• Custom Peptide Synthesis: Essential raw material for CROs (Contract Research Organizations) and CDMOs (Contract Development and Manufacturing Organizations) offering bespoke peptide production services.
• Academic Research: Used in university and institutional labs for fundamental studies in peptide chemistry, medicinal chemistry, and structural biology.

Basic Information

Product Name	H-Ala-Glu(Otbu)-Nh2 Hcl
CAS No.	108607-07-4
Molecular Formula	C₁₂H₂₄N₃O₅ • HCl
Molecular Weight	335.80 g/mol
Synonyms	L-Alanyl-L-glutamic acid α-tert-butyl ester amide hydrochloride; H-Ala-Glu(OtBu)-NH₂ • HCl; Ala-Glu(OtBu)-NH₂ hydrochloride; N-(tert-Butoxycarbonyl)-L-alanyl-L-glutamic acid α-tert-butyl ester amide hydrochloride (related protected form); Fmoc-Ala-Glu(OtBu)-NH₂ (related protected form); Protected Ala-Glu dipeptide amide; A-E(OtBu)-NH₂ • HCl
EINECS	Contact for details

Quality Control

Every batch of H-Ala-Glu(Otbu)-Nh2 Hcl is manufactured under strict quality management systems and undergoes comprehensive analytical testing to ensure identity, purity, and consistency. We provide full traceability and Certificates of Analysis (COA) detailing specifications such as assay (HPLC), chiral purity, and residual solvent levels. Our production adheres to cGMP guidelines where applicable, supporting its use in advanced research and pre-clinical development phases.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive); therefore, the container must be kept tightly sealed in a dry environment to prevent degradation. For long-term storage, consider desiccated conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0% (L-isomer)
Water Content (KF)	≤ 1.0%
Residual Solvents (GC)	Complies with ICH limits
Heavy Metals	< 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.