Description

Calcitonin Gene-Related Peptide, Asu(2,7)- CAS NO 108568-91-8 is a synthetic analogue of the potent vasodilator neuropeptide CGRP, engineered with amino acid substitutions at positions 2 and 7 to enhance its stability and biological activity. This modified peptide is a critical research tool for studying neurovascular physiology, pain signaling pathways, and migraine mechanisms. It is essential for pharmaceutical R&D, academic research, and diagnostic development in the fields of neuroscience and cardiovascular biology.

Application

• Neuroscience Research: Used as a reference standard and active agent in studies of CGRP receptor binding, neuronal signaling, and neurogenic inflammation.
• Migraine & Pain Research: A key compound for investigating the pathophysiology of migraines and developing novel analgesic and anti-migraine therapeutics.
• Cardiovascular Studies: Employed in research on vascular tone regulation, blood flow, and endothelial function due to its potent vasodilatory properties.
• Pharmaceutical Development: Serves as a critical intermediate or reference material in the development and validation of CGRP-targeting drugs and biologics.
• Diagnostic Assay Development: Used in the calibration and development of immunoassays (e.g., ELISA, RIA) for detecting CGRP levels in biological samples.
• Cell Biology & Signal Transduction: Applied in vitro to study intracellular signaling cascades activated by the CGRP receptor in relevant cell lines.

Basic Information

Product Name	Calcitonin Gene-Related Peptide, Asu(2,7)- CAS NO 108568-91-8
CAS No.	108568-91-8
Molecular Formula	C145H244N44O42S2
Molecular Weight	~ 3790.0 g/mol
Synonyms	Asu(2,7)-CGRP; [Asu2,7]-hCGRPα; Human CGRP I (Asu2,7); Calcitonin Gene-Related Peptide (Asu2,7 analogue); CGRP (2-7 amino-suberic acid); hCGRPα-(Asu2,7); CGRP analogue; [Amino-suberic acid2,7]-CGRP
EINECS	Contact for details

Quality Control

Our Calcitonin Gene-Related Peptide, Asu(2,7)- is manufactured under strict quality systems. Each batch is characterized and tested to ensure high purity and batch-to-batch consistency, meeting the rigorous standards required for research and development. Comprehensive analytical data, including HPLC purity, MS confirmation, and peptide content, are documented. A Certificate of Analysis (COA) is provided with every shipment to guarantee product integrity and traceability.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below. This product is hygroscopic (moisture-sensitive). For long-term storage, keep desiccated. Aliquot to avoid repeated freeze-thaw cycles.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical molecular weight
Purity (HPLC)	≥ 95.0%
Peptide Content	≥ 80.0% (by weight)
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC)	≤ 10.0%
Single Impurity (HPLC)	≤ 1.0%
Biological Activity	Assessed by functional assay (e.g., cAMP induction)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.