Description

Z-Val-Met-Oh is a protected dipeptide building block, specifically the Cbz-protected derivative of Valyl-Methionine. This compound is a critical intermediate in the synthesis of complex peptides and peptidomimetics, offering precise control over sequence and stereochemistry. It is primarily utilized by pharmaceutical R&D departments and fine chemical manufacturers engaged in the development of therapeutic peptides, protease inhibitors, and novel bioactive molecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key protected fragment for the sequential assembly of longer peptide chains in both Fmoc and Boc strategies.
• Solution-Phase Peptide Synthesis: Used as a coupling unit in the synthesis of peptide segments and small peptides in solution.
• Pharmaceutical Intermediate: Serves as a crucial building block in the research and development of potential peptide-based drugs and diagnostic agents.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, particularly with proteases, and in the preparation of enzyme inhibitors.
• Production of Custom Peptides: Used by CROs and CDMOs for the contract manufacturing of specific peptide sequences for clients.
• Academic Research: A valuable reagent for university and institutional labs studying peptide chemistry, structure-activity relationships (SAR), and medicinal chemistry.

Basic Information

Product Name	Z-Val-Met-Oh
CAS No.	108543-82-4
Molecular Formula	C19H28N2O5S
Molecular Weight	396.50 g/mol
Synonyms	N-Carbobenzoxy-L-valyl-L-methionine; Cbz-Val-Met-OH; Z-L-Val-L-Met-OH; Nα-(Benzyloxycarbonyl)-L-valyl-L-methionine; Benzyl N-[(2S)-1-[[(2S)-2-amino-4-methylsulfanyl-1-oxobutan-2-yl]amino]-3-methyl-1-oxobutan-2-yl]carbamate; CBZ-Val-Met; Z-Val-Met; Z-Val-Met-OH
EINECS	Contact for details

Quality Control

Our Z-Val-Met-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis for enantiomeric excess, and identity confirmation via spectroscopic methods. We provide full traceability and a Certificate of Analysis (COA) with every shipment, ensuring compliance with your research and development specifications.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 15-25°C. This material is hygroscopic (moisture-sensitive) and should be handled in a dry environment to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation [α]	Contact for details
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.5%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.