Description

4-Benzyloxy-2-Chloropyrimidine is a versatile halogenated pyrimidine derivative that serves as a critical building block in advanced organic synthesis. This compound is valued for its reactive chloropyrimidine core, which enables selective functionalization, making it an essential intermediate for pharmaceutical and agrochemical research. It is primarily sought after by R&D chemists and process development scientists in the fine chemical, pharmaceutical, and agrochemical industries for constructing complex molecular architectures.

Application

• Pharmaceutical Intermediate: Key precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for kinase inhibitors and other small molecule therapeutics.
• Agrochemical Synthesis: Building block for developing novel herbicides, fungicides, and plant growth regulators.
• Material Science Research: Used in the development of organic semiconductors, liquid crystals, and advanced polymers.
• Cross-Coupling Reactions: Serves as a substrate in Suzuki, Stille, and other palladium-catalyzed cross-coupling reactions to form biaryl structures.
• Nucleophilic Substitution: The chlorine atom at the 2-position is readily displaced by various nucleophiles (amines, alkoxides) to create diverse pyrimidine libraries.
• Chemical Biology Probes: Useful for synthesizing labeled compounds and probes for studying biological mechanisms.

Basic Information

Product Name	4-Benzyloxy-2-Chloropyrimidine
CAS No.	108381-28-8
Molecular Formula	C11H9ClN2O
Molecular Weight	220.65 g/mol
Synonyms	2-Chloro-4-(phenylmethoxy)pyrimidine; 4-(Benzyloxy)-2-chloropyrimidine; 2-Chloro-4-benzyloxypyrimidine; 4-Benzyloxy-2-chloro-pyrimidine; 2-Chloro-4-(benzyloxy)pyrimidine; Pyrimidine, 2-chloro-4-(phenylmethoxy)-; 108381-28-8
EINECS	Contact for details

Quality Control

Our 4-Benzyloxy-2-Chloropyrimidine is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC, NMR, and GC-MS, to ensure identity, purity, and consistency. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all critical quality attributes. Our quality commitment aligns with cGMP principles for pharmaceutical intermediates, ensuring reliability for your most demanding synthesis workflows.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Keep the container tightly sealed to prevent moisture absorption and contamination. Store away from incompatible materials.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Purity (HPLC)	≥ 98.0%
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.