Description

Z-Asp(Osu)-Obzl is a protected aspartic acid derivative, specifically an N-benzyloxycarbonyl aspartic acid β-benzyl ester activated with an N-hydroxysuccinimide (Osu) ester group. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled and efficient incorporation of aspartic acid while preventing unwanted side reactions. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, peptide hormones, and complex biomolecules.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key protected and activated amino acid derivative for the sequential assembly of peptide chains.
• Pharmaceutical Intermediates: Synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs targeting metabolic disorders, cancer, and infectious diseases.
• Bioconjugation: Used to introduce aspartic acid residues or carboxylic acid handles into proteins, antibodies, or other biomolecules for labeling or functionalization.
• Research & Development: A vital reagent in academic and industrial R&D for exploring new peptide structures, peptidomimetics, and drug candidates.
• Custom Peptide Production: Employed by CROs and CDMOs for the reliable and scalable manufacture of custom peptides for clients.

Basic Information

Product Name	Z-Asp(Osu)-Obzl
CAS No.	108325-86-6
Molecular Formula	C23H23N2O8
Molecular Weight	455.44 g/mol
Synonyms	Nα-Benzyloxycarbonyl-L-aspartic acid β-benzyl ester N-hydroxysuccinimide ester; Z-L-Aspartic acid β-benzyl ester N-succinimidyl ester; Z-Asp(OBzl)-OSu; N-Cbz-L-aspartic acid 4-benzyl ester N-succinimidyl ester; Benzyl N-[(benzyloxy)carbonyl]-L-β-aspartyl succinimido carbonate; (S)-2-(((Benzyloxy)carbonyl)amino)-4-((((benzyloxy)carbonyl)oxy)amino)-4-oxobutanoic acid; Aspartic acid derivative (protected); Peptide synthesis reagent
EINECS	Contact for details

Quality Control

Our Z-Asp(Osu)-Obzl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and chiral integrity, NMR for structural confirmation, and KF titration for moisture content. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with your research or cGMP-grade requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a freezer at -20°C or below. Due to its hygroscopic (moisture-sensitive) nature, the container should be allowed to equilibrate to room temperature before opening to prevent condensation. For long-term stability, store under an inert atmosphere such as argon or nitrogen.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (HPLC)	Conforms to reference standard
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Optical Rotation [α]D20	-15.0° to -18.0° (c=1 in DMF)
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.