Description

H-Phe-Amc Tfa is a specialized protected amino acid derivative, widely recognized as a crucial building block in peptide synthesis. This compound matters for its role in facilitating the controlled assembly of complex peptides, ensuring high coupling efficiency and purity in the final product. It is primarily needed by research institutions and pharmaceutical companies engaged in the development of novel therapeutic peptides, diagnostic agents, and biochemical probes. Its reliable performance makes it a staple in both laboratory-scale research and larger-scale cGMP manufacturing processes.

Application

• Solid-Phase Peptide Synthesis (SPPS): As a key Fmoc-protected amino acid derivative for the sequential construction of peptide chains.
• Solution-Phase Peptide Synthesis: Used in classical coupling reactions for producing custom peptides and peptide fragments.
• Pharmaceutical Intermediate: Serves as a critical raw material in the synthesis of active pharmaceutical ingredients (APIs) for peptide-based drugs.
• Biochemical Research: Employed in studies of enzyme-substrate interactions, protease activity assays, and as a substrate analog.
• Combinatorial Chemistry: Utilized in libraries for high-throughput screening to discover new bioactive compounds.
• Proteomics and Diagnostics: Acts as a component in the development of fluorescent or chromogenic substrates for detecting specific enzymatic activities.

Basic Information

Product Name	H-Phe-Amc Tfa
CAS No.	108321-84-2
Molecular Formula	C₂₁H₂₁F₃N₂O₄
Molecular Weight	422.40 g/mol
Synonyms	Fmoc-Phe-AMC; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-phenylalanyl-7-amino-4-methylcoumarin; Fmoc-L-Phenylalanine 7-amido-4-methylcoumarin; Fmoc-Phe-AMC trifluoroacetate salt; L-Phenylalanine, N-[(9H-fluoren-9-ylmethoxy)carbonyl]-, 1-(7-amino-4-methyl-2-oxo-2H-1-benzopyran-3-yl) ester; Fmoc-Phe-AMC TFA; Fmoc-Phe-AMC trifluoroacetic acid salt; Fmoc-L-Phe-AMC
EINECS	Contact for details

Quality Control

Our H-Phe-Amc Tfa is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for sensitive research and production applications. Each lot undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation. A detailed Certificate of Analysis (COA) is provided with every shipment, documenting the specific results for your quality assurance records. We adhere to industry best practices to support your compliance needs in regulated environments.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept sealed in a dry environment to prevent degradation. For long-term storage, consider desiccants or inert atmosphere conditions.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms
Identification (IR)	Conforms
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.