Description

n-Formyl-Met-Leu-Phe p-Fluorobenzylamide is a synthetic, formylated tripeptide derivative designed for advanced biochemical and pharmacological research. This compound serves as a potent and selective formyl peptide receptor (FPR) agonist, making it a critical tool for studying neutrophil chemotaxis and inflammatory signaling pathways. It is primarily utilized by researchers and developers in the pharmaceutical, biotechnology, and life sciences sectors for drug discovery, immunology studies, and the development of anti-inflammatory therapeutics.

Application

• Biochemical Research: As a standard agonist for formyl peptide receptors (FPR1/FPR2) in studies of innate immunity, leukocyte activation, and chemotaxis.
• Drug Discovery & Screening: Used in high-throughput screening (HTS) assays to identify novel FPR antagonists or modulators for inflammatory diseases.
• Inflammation & Immunology Studies: A key reagent for modeling and investigating the molecular mechanisms of acute and chronic inflammatory responses.
• Signal Transduction Research: Employed to elucidate G-protein coupled receptor (GPCR) signaling cascades and downstream effector pathways.
• Pharmaceutical Development: Serves as a reference compound and pharmacophore model in the design of new anti-inflammatory or immunomodulatory agents.
• Academic & Clinical Research: Used in university and hospital laboratories for fundamental research into neutrophil biology and related pathologies.

Basic Information

Product Name	n-Formyl-Met-Leu-Phe p-Fluorobenzylamide
CAS No.	108321-41-1
Molecular Formula	C33H46FN5O5S
Molecular Weight	643.82 g/mol
Synonyms	fMLF-p-Fluorobenzylamide; N-Formyl-Met-Leu-Phe-p-Fluorobenzyl Amide; Formyl-Met-Leu-Phe-p-Fluorobenzylamide; fMLP-p-FBZA; fMLF-p-FBA; Formyl Peptide Receptor Agonist; fMLF Analog; Chemotactic Peptide Derivative; For-Met-Leu-Phe-p-Fluorobenzylamide
EINECS	Contact for details

Quality Control

Our n-Formyl-Met-Leu-Phe p-Fluorobenzylamide is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, MS and NMR for structural confirmation, and stringent controls for residual solvents and related substances. A detailed Certificate of Analysis (COA) is provided with every shipment, ensuring traceability and compliance with research-grade specifications.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). For long-term storage, consider desiccant and under an inert atmosphere. Allow the vial to equilibrate to room temperature before opening to minimize moisture condensation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to structure
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Heavy Metals	≤ 20 ppm
Residual Solvents (GC)	Complies with ICH guidelines
Biological Activity (Cell-based assay)	EC50 as per reference

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.