Description

Fmoc-D-Asparagine CAS NO 108321-39-7 is a protected amino acid derivative where the α-amino group is blocked by a 9-fluorenylmethoxycarbonyl (Fmoc) group, and the side chain features an amide functionality. This compound is a critical building block in solid-phase peptide synthesis (SPPS), enabling the controlled, sequential assembly of complex peptides and proteins. It is primarily utilized by researchers and manufacturers in the pharmaceutical, biotechnology, and life sciences industries for the development of therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A fundamental Fmoc-protected amino acid for the automated or manual synthesis of custom peptides.
• Pharmaceutical Research & Development: Used in the discovery and production of peptide-based drugs, including hormones, antibiotics, and enzyme inhibitors.
• Bioconjugation & Protein Engineering: Serves as a precursor for introducing asparagine residues or amide-containing side chains into engineered proteins and antibody-drug conjugates (ADCs).
• Combinatorial Chemistry: Employed in the generation of diverse peptide libraries for high-throughput screening against biological targets.
• Biochemical Reagent Production: A key raw material for manufacturing specialized reagents, substrates, and standards used in enzymatic assays and analytical methods.
• Academic & Institutional Research: Essential for basic research in biochemistry, molecular biology, and structural biology to study protein function and interactions.

Basic Information

Product Name	Fmoc-D-Asparagine
CAS No.	108321-39-7
Molecular Formula	C19H18N2O5
Molecular Weight	354.36 g/mol
Synonyms	Fmoc-D-Asn-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-D-asparagine; (R)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-carbamoylpropanoic acid; D-2-[(9-Fluorenylmethoxycarbonyl)amino]succinamic acid; Fmoc-D-Asp-NH2; Nα-Fmoc-D-asparagine; Fmoc-D-Asparagine, Fmoc protected; N-Fmoc-D-asparagine
EINECS	Contact for details

Quality Control

Our Fmoc-D-Asparagine is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot undergoes comprehensive analytical testing, including HPLC for purity assessment, chiral analysis to confirm stereochemical integrity, and identity confirmation via spectroscopic methods. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This material is hygroscopic (moisture-sensitive) and should be handled under dry conditions to prevent degradation. For long-term storage, consider desiccation.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥98.0%
Optical Rotation	Contact for details
Chiral Purity (HPLC)	≥99.0% (D-isomer)
Water Content (KF)	≤1.0%
Heavy Metals	≤20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.