Description

n-α-(3-Nitro-2-Pyridinesulfenyl)-n-Im-Tosyl-L-Histidine is a specialized, high-purity chemical building block used in advanced organic synthesis and pharmaceutical research. This compound is valued for its role as a key intermediate in the development of novel peptide-based therapeutics and biochemical probes. It is primarily required by research institutions, pharmaceutical R&D departments, and fine chemical manufacturers focused on drug discovery and process development.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of complex peptide drugs and targeted therapeutic agents.
• Bioconjugation Reagent: Used for site-specific modification of proteins, antibodies, and other biomolecules in bioconjugation chemistry.
• Protecting Group Chemistry: Serves as a specialized protecting group for histidine residues during solid-phase peptide synthesis (SPPS).
• Chemical Biology Research: Employed in the development of activity-based probes and enzyme inhibitors for biochemical studies.
• Process Development: Used in scaling up synthetic routes for active pharmaceutical ingredients (APIs) under Good Manufacturing Practice (GMP) conditions.

Basic Information

Product Name	n-α-(3-Nitro-2-Pyridinesulfenyl)-n-Im-Tosyl-L-Histidine
CAS No.	108312-26-1
Molecular Formula	C18H17N5O6S2
Molecular Weight	463.49 g/mol
Synonyms	N-α-(3-Nitro-2-pyridinesulfenyl)-N-im-tosyl-L-histidine; (S)-2-((3-Nitro-2-pyridinyl)thio)-1-((4-methylphenyl)sulfonyl)-1H-imidazole-4-carboxylic acid; N-α-(3-Nitro-2-pyridylthio)-N-im-tosyl-L-histidine; 3-Nitro-2-pyridinesulfenyl tosyl histidine derivative; L-Histidine, N-[(3-nitro-2-pyridinyl)thio]-N-[(4-methylphenyl)sulfonyl]-; Tosyl-3-nitro-2-pyridinesulfenyl histidine; SPyS-Tosyl-His-OH
EINECS	Contact for details

Quality Control

Our n-α-(3-Nitro-2-Pyridinesulfenyl)-n-Im-Tosyl-L-Histidine is manufactured under strict quality control protocols to ensure batch-to-batch consistency and high purity suitable for research and development. We provide comprehensive Certificates of Analysis (COA) with each batch, detailing purity, identity, and impurity profiles. Our quality system supports compliance with cGMP standards for pharmaceutical intermediates.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This compound is light-sensitive and should be handled under appropriate conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Specific Rotation	Contact for details
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.