Description

L-Lysine, [4,5-3H(N)]- is a high-specific-activity, tritium-labeled derivative of the essential amino acid L-Lysine, identified by CAS No. 108158-27-6. This radiolabeled compound is a critical tool for researchers requiring precise metabolic and pharmacokinetic tracing in biological systems. It is primarily utilized in life science research, pharmaceutical development, and biochemical studies where tracking amino acid uptake, protein synthesis, and metabolic pathways is essential.

Application

• Metabolic Pathway Tracing: Used as a radiotracer to study the metabolism, distribution, and utilization of L-Lysine in vivo and in vitro.
• Protein Synthesis & Turnover Studies: Essential for investigating the rates of protein synthesis, degradation, and turnover in cell cultures and animal models.
• Pharmacokinetics & Drug Metabolism (ADME): Employed in Absorption, Distribution, Metabolism, and Excretion (ADME) studies for lysine-containing drugs or peptides.
• Biochemical Assay Development: Serves as a key component in developing and validating receptor-binding assays, enzyme activity tests, and transport studies.
• Nutritional Research: Applied in studies examining lysine requirements, bioavailability, and its role in animal and human nutrition.
• Autoradiography & Imaging: Suitable for use in tissue autoradiography and other imaging techniques to visualize spatial distribution.

Basic Information

Product Name	L-Lysine, [4,5-3H(N)]-
CAS No.	108158-27-6
Molecular Formula	C6H14N2O2 (³H-labeled)
Molecular Weight	Contact for details (varies with specific activity)
Synonyms	(2S)-2,6-Diamino[4,5-³H]hexanoic acid; Tritiated L-Lysine; L-Lysine-4,5-³H; [4,5-³H]-L-Lysine; H-Lys-OH-4,5-³H; (S)-2,6-Diamino[4,5-³H₂]caproic acid; Lysine-4,5-t; ³H-L-Lysine
EINECS	Contact for details

Quality Control

Every batch of L-Lysine, [4,5-3H(N)]- is manufactured and analyzed under strict quality systems to ensure high radiochemical purity and specific activity. Quality is verified by advanced analytical techniques including HPLC with radiometric detection. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing specific activity, radiochemical purity, chemical purity, and solvent composition. Our production adheres to GMP principles suitable for research use.

Storage

Preserve in a tightly closed container, protected from light. Store frozen (-20°C or below) in the original solvent as supplied. For long-term storage, keep at -70°C to -80°C. The product is strictly light-sensitive (protect from all light exposure). Always handle with appropriate safety measures for radioactive materials in a designated laboratory area.

Specification

Item	Specification
Appearance	Clear, colorless to slightly yellow solution
Specific Activity	Contact for details (typically 40-80 Ci/mmol)
Radiochemical Purity	≥ 95% (by HPLC)
Chemical Purity	≥ 98%
Concentration	1 mCi/mL (as specified on COA)
Solvent	Ethanol:Water mixture (as specified on COA)
Identification	Co-chromatography with reference standard (HPLC)

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.