Description

Fibronectin Type III Connecting Segment Fragment 1-25 is a synthetic peptide fragment derived from the cell-binding domain of human fibronectin. This compound is a critical research tool for studying cell adhesion, migration, and signaling pathways mediated by integrin receptors. It is primarily utilized by biotechnology and pharmaceutical R&D teams focused on oncology, wound healing, and tissue engineering applications. The peptide's defined sequence allows for precise investigation of protein-protein interactions fundamental to cellular behavior.

Application

• Biomedical Research: Used as a key reagent in studies of integrin-mediated cell adhesion, spreading, and cytoskeletal organization.
• Drug Discovery Screening: Serves as a target or competitor in high-throughput assays to identify novel therapeutic compounds that modulate cell-matrix interactions.
• Tissue Engineering: Applied to functionalize biomaterial surfaces (e.g., hydrogels, polymers) to enhance specific cellular attachment and growth.
• Cancer Research: Investigated for its role in tumor cell metastasis, angiogenesis, and the tumor microenvironment.
• Wound Healing Studies: Employed in models to understand and promote fibroblast migration and tissue regeneration.
• Biomarker Development: Potential use in developing diagnostic tools for diseases involving altered fibronectin-integrin signaling.

Basic Information

Product Name	Fibronectin Type III Connecting Segment Fragment 1-25
CAS No.	107978-77-8
Molecular Formula	C129H204N38O39
Molecular Weight	2843.2 g/mol
Synonyms	Fibronectin Cell-Binding Domain Fragment; CS1 Peptide (1-25); FN III CS1 (1-25); LDV Peptide; Arg-Gly-Asp-Ser (RGDS) containing peptide; Fibronectin Connecting Segment-1 Fragment; Human Fibronectin Peptide (CS1 region); Adhesion Peptide
EINECS	Contact for details

Quality Control

Our Fibronectin Type III Connecting Segment Fragment 1-25 is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot is characterized by advanced analytical techniques including HPLC for purity and MS for sequence confirmation. We provide comprehensive Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels, supporting research requiring reliable and reproducible performance.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a dry environment before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to structure
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80%
Amino Acid Analysis	Within ± 10% of theoretical
Water Content (KF)	≤ 5.0%
Endotoxin	< 10 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.