Description

Dendrotoxin I is a highly specific and potent polypeptide neurotoxin isolated from the venom of the Eastern green mamba (*Dendroaspis angusticeps*). Its primary value lies in its selective blockade of voltage-gated potassium channels, particularly the Kv1.1, Kv1.2, and Kv1.6 subtypes, making it an indispensable research tool in neuroscience and pharmacology. This compound is essential for scientists and institutions engaged in ion channel research, neurological disorder modeling, and the development of novel therapeutic agents.

Application

• Neuroscience Research: A critical tool for studying the structure, function, and pharmacology of voltage-gated potassium (Kv) channels in neuronal signaling.
• Electrophysiology: Used in patch-clamp and other electrophysiological assays to selectively inhibit specific Kv channel subtypes to elucidate their role in action potential generation and neuronal excitability.
• Drug Discovery & Development: Serves as a reference standard and pharmacological probe in high-throughput screening (HTS) campaigns aimed at discovering new potassium channel modulators for treating epilepsy, autoimmune diseases, and pain.
• Biochemical Assays: Employed in binding studies and competitive displacement assays to characterize receptor-ligand interactions and determine binding affinities for novel compounds.
• Toxicology & Venom Research: Used as a purified component for studying the mechanisms of mamba envenomation and for the development of specific antivenoms or therapeutic countermeasures.
• Academic & Institutional Research: Supplied to universities, government labs, and pharmaceutical R&D departments for fundamental and applied research programs.

Basic Information

Product Name	Dendrotoxin I
CAS No.	107950-33-4
Molecular Formula	C184H282N52O53S7
Molecular Weight	Approx. 4200 Da
Synonyms	DTX-I; Dendrotoxin K; Toxin K; Dendrotoxin, Dendroaspis angusticeps; Dendrotoxin alpha; Potassium channel toxin α-Dtx; ShK-like toxin 1; α-Dendrotoxin
EINECS	Contact for details

Quality Control

Every batch of Dendrotoxin I is produced and analyzed under stringent conditions to ensure the highest standards of purity and biological activity, suitable for critical research applications. Our quality assurance includes rigorous testing for identity, purity, and potency. A comprehensive Certificate of Analysis (COA) is provided with each shipment, detailing analytical results from methods including HPLC, mass spectrometry, and functional activity assays.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store lyophilized material at -20°C or below. Reconstituted solutions should be aliquoted to avoid repeated freeze-thaw cycles and stored at -80°C. This product is hygroscopic (moisture-sensitive); ensure the container is sealed under anhydrous conditions after each use.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC/MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Potency (Functional Assay)	≥ 98%
Endotoxin Level	< 1.0 EU/µg
Solubility	Soluble in water or aqueous buffers

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.