Description

H-Pro-Asn-Oh is a protected dipeptide building block, specifically the C-terminal carboxylic acid of the Pro-Asn sequence. This compound is a critical intermediate in the solid-phase and solution-phase synthesis of complex peptides and peptidomimetics, offering precise control over molecular structure. It is essential for researchers and manufacturers in the pharmaceutical and biotechnology sectors developing therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Pharmaceutical Intermediates: Key building block for the synthesis of novel therapeutic peptides targeting metabolic disorders, oncology, and infectious diseases.
• Biochemical Research: Used in academic and industrial R&D for studying enzyme-substrate interactions, protein folding, and signal transduction pathways.
• Peptide Library Synthesis: Enables the creation of diverse combinatorial libraries for high-throughput screening in drug discovery campaigns.
• Cosmeceutical Actives: Serves as a precursor for synthesizing bioactive peptide sequences used in advanced skincare formulations for anti-aging and repair.
• Diagnostic Reagent Development: Employed in the design and production of peptide-based biomarkers, assay components, and imaging probes.

Basic Information

Product Name	H-Pro-Asn-Oh
CAS No.	107856-82-6
Molecular Formula	C9H15N3O4
Molecular Weight	229.23 g/mol
Synonyms	L-Prolyl-L-asparagine; Pro-Asn-OH; H-Pro-Asn-OH; L-Pro-L-Asn; N-(L-α-AsparaginyL)-L-proline; (S)-2-((S)-2-Aminopropanamido)-5-azidopentanoic acid (related); Fmoc-Pro-Asn-OH (protected variant); Z-Pro-Asn-OH (protected variant)
EINECS	Contact for details

Quality Control

Our H-Pro-Asn-Oh is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis to confirm stereochemical integrity, and residual solvent screening. Certificates of Analysis (COA) detailing all specifications are provided to ensure traceability and compliance with your research or cGMP guidelines.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at 2-8°C. This product is hygroscopic (moisture-sensitive). Allow the container to reach room temperature before opening to minimize moisture absorption. For long-term storage, consider desiccant or under an inert atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Optical Rotation	-70° to -80° (c=1 in H2O)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.