Description

Pyroglutamyl-((N3)-Imidazolylmethyl)-Histidyl-n-Amylprolinamide is a synthetic peptide compound of significant interest in advanced biochemical research and development. This molecule is valued for its specific structural motifs, including the pyroglutamyl and imidazolylmethyl groups, which are key to its biological activity and interaction profiles. It is primarily utilized by researchers and developers in the pharmaceutical and biotechnology sectors, particularly in the exploration of novel therapeutic agents, enzyme inhibitors, and as a sophisticated biochemical tool in peptide-based studies.

Application

• Pharmaceutical Research: Serves as a key intermediate or active scaffold in the development of novel drug candidates, particularly for targeting specific enzymatic pathways.
• Biochemical Tool Compound: Used in in vitro assays to study receptor-ligand interactions, enzyme kinetics, and cellular signaling mechanisms.
• Peptide Chemistry Studies: Acts as a model compound for investigating peptide synthesis strategies, stability, and structure-activity relationships (SAR).
• Academic & Institutional R&D: Employed in university and research institute laboratories for fundamental studies in medicinal chemistry and molecular biology.
• High-Throughput Screening (HTS): Can be incorporated into compound libraries for screening against various biological targets to identify potential leads.
• Custom Synthesis & Contract Manufacturing: Sourced by CDMOs (Contract Development and Manufacturing Organizations) for the production of specialized, non-commercial quantities for client research programs.

Basic Information

Product Name	Pyroglutamyl-((N3)-Imidazolylmethyl)-Histidyl-n-Amylprolinamide
CAS No.	107810-09-3
Molecular Formula	C26H38N8O4
Molecular Weight	526.63 g/mol
Synonyms	Pyroglutamyl-(N(3)-imidazolylmethyl)-histidyl-n-amylprolinamide; L-Pyroglutamyl-[N(3)-(imidazol-4-ylmethyl)-L-histidyl]-L-norleucyl-L-prolinamide; (S)-1-((S)-2-((S)-2-((S)-5-Oxo-2-pyrrolidinecarboxamido)-3-(1H-imidazol-5-yl)propanamido)-3-(1H-imidazol-4-yl)propanamido)hexanoyl)pyrrolidine-2-carboxamide; PG-ImH-Nle-P-NH2 (abbreviated); A Peptide Inhibitor (context-dependent); Contact for additional trade names.
EINECS	Contact for details

Quality Control

Every batch of Pyroglutamyl-((N3)-Imidazolylmethyl)-Histidyl-n-Amylprolinamide is produced and analyzed under strict quality management protocols to ensure identity, purity, and consistency. Our products undergo rigorous quality testing to ensure compliance with industry standards. Certificates of Analysis (COA) are available upon request, detailing key parameters such as assay purity, chiral purity, and impurity profiles as determined by advanced analytical techniques including HPLC and MS.

Storage

Preserve in a tightly closed container, protected from light. Store at controlled room temperature (15-25°C) or as indicated on the label. This product is hygroscopic (moisture-sensitive) and should be handled in a dry environment. For long-term storage, consider desiccated conditions. Keep container tightly sealed when not in use to prevent degradation.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Purity (HPLC, Total)	≥ 98.0%
Water Content (KF)	≤ 5.0%
Residue on Ignition	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.