Description

Amyloid β-Peptide (1-42) (Human) CAS NO 107761-42-2 is a synthetic 42-amino acid peptide fragment corresponding to the amyloid-beta protein, a key component in the pathology of Alzheimer's disease. This high-purity reference standard is critical for advancing neurological research and therapeutic development. It is an essential reagent for researchers and pharmaceutical companies focused on neurodegenerative disease modeling, drug screening, and biomarker discovery.

Application

• Neuroscience Research: Primary tool for studying the aggregation kinetics, neurotoxicity, and molecular mechanisms of amyloid-beta plaques in Alzheimer's disease models.
• Drug Discovery & Screening: Used as a target compound in high-throughput assays to identify and evaluate potential inhibitors of Aβ aggregation and toxicity.
• Biomarker Development: Serves as a critical standard in immunoassays (ELISA, Western Blot) for the detection and quantification of Aβ peptides in biological samples.
• In Vitro & In Vivo Modeling: Essential for creating cellular and animal models of Alzheimer's disease to study disease progression and test therapeutic interventions.
• Antibody & Diagnostic Kit Production: Used as an immunogen for generating specific antibodies and as a calibrator in diagnostic kit development.
• Structural Biology Studies: Key material for investigating the secondary and tertiary structure of amyloid-beta fibrils using techniques like NMR and X-ray crystallography.

Basic Information

Product Name	Amyloid β-Peptide (1-42) (Human)
CAS No.	107761-42-2
Molecular Formula	C203H311N55O60S
Molecular Weight	4514.1 g/mol
Synonyms	Aβ42; Aβ(1-42); Amyloid β-Protein (1-42); β-Amyloid Peptide (1-42); Amyloid β (1-42); Amyloid β-Peptide (1-42); Alzheimer's Disease Amyloid Peptide; DAEFRHDSGYEVHHQKLVFFAEDVGSNKGAIIGLMVGGVVIA
EINECS	Contact for details

Quality Control

Our Amyloid β-Peptide (1-42) (Human) is manufactured under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical testing, including HPLC for purity verification and mass spectrometry for identity confirmation. We provide full traceability and Certificates of Analysis (COA) detailing purity, peptide content, and endotoxin levels to support your regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store desiccated at -20°C or below. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to prevent condensation and moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 70% (by weight)
Molecular Weight	4514.1 ± 2.0 Da (by Mass Spectrometry)
Solubility	Soluble in 1% NH₄OH or DMSO
Endotoxin Level	< 1.0 EU/mg

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.