Description

Umespirone CAS NO 107736-98-1 is a high-purity pharmaceutical intermediate and research chemical belonging to the azapirone class. This compound is of significant interest for its role in the development and synthesis of novel therapeutic agents targeting the central nervous system. It is primarily utilized by pharmaceutical R&D laboratories, contract manufacturing organizations (CMOs), and academic research institutions engaged in neuropharmacology and drug discovery.

Application

• Pharmaceutical Intermediate: Key building block in the synthesis of advanced active pharmaceutical ingredients (APIs) with psychotropic activity.
• Neuropharmacology Research: Used as a reference standard and precursor in studies investigating serotonin (5-HT1A) receptor agonists and anxiolytic agents.
• Preclinical Development: Serves as a critical material in the preclinical stages of drug development for neurological and psychiatric disorders.
• Chemical Synthesis: Employed in organic synthesis for constructing complex heterocyclic structures relevant to medicinal chemistry.
• Analytical Standard: Provides a high-purity standard for quality control (QC) and analytical method development (e.g., HPLC, LC-MS) in pharmaceutical manufacturing.
• Academic & Institutional Research: Supports fundamental research in universities and government labs exploring new mechanisms of action for CNS-targeting drugs.

Basic Information

Product Name	Umespirone
CAS No.	107736-98-1
Molecular Formula	C19H25N5O2
Molecular Weight	355.44 g/mol
Synonyms	Umespirone; 8-[4-[4-(Pyrimidin-2-yl)piperazin-1-yl]butyl]-8-azaspiro[4.5]decane-7,9-dione; 107736-98-1; UNII-6W3A8XW2AM; 6W3A8XW2AM; Spiro[8-azabicyclo[3.2.1]octane-3,5'(4'H)-pyrimidine]-8,8'(7'H)-dione, 1'-[4-[4-(2-pyrimidinyl)-1-piperazinyl]butyl]-, (1'alpha,5'alpha)-; (1'alpha,5'alpha)-1'-[4-[4-(2-Pyrimidinyl)-1-piperazinyl]butyl]spiro[8-azabicyclo[3.2.1]octane-3,5'(4'H)-pyrimidine]-8,8'(7'H)-dione
EINECS	Contact for details

Quality Control

Our Umespirone is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research and development. Production adheres to cGMP guidelines where applicable. Each batch is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles as determined by advanced analytical techniques including HPLC, GC, and NMR.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Residual Solvents (GC)	Meets ICH Q3C guidelines
Water Content (KF)	≤ 0.5%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.