Description

9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid is a high-purity, advanced pharmaceutical intermediate of significant commercial and research importance. This compound is a key building block in the synthesis of modern fluoroquinolone antibiotics, valued for its precise molecular structure that imparts critical biological activity. It is essential for manufacturers and R&D laboratories in the pharmaceutical and fine chemical sectors focused on developing new antibacterial agents.

Application

• Pharmaceutical Intermediate: Primary use as a critical precursor in the synthesis of novel fluoroquinolone antibiotic APIs (Active Pharmaceutical Ingredients).
• Antibacterial Drug Development: Serves as a core scaffold in medicinal chemistry research for creating next-generation antibacterial compounds with improved efficacy.
• Fine Chemical Synthesis: Used in complex organic synthesis for constructing fused heterocyclic systems in specialty chemicals.
• Contract Research & Manufacturing (CRAM): Supplied to CDMOs (Contract Development and Manufacturing Organizations) for custom synthesis and scale-up projects.
• Academic & Industrial R&D: Employed in research institutions for studying structure-activity relationships (SAR) of quinolone derivatives.

Basic Information

Product Name	9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid
CAS No.	107358-77-0
Molecular Formula	C14H10F2N2O4
Molecular Weight	308.24 g/mol
Synonyms	9,10-Difluoro-2,3-dihydro-2-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid; 9,10-Difluoro-2-methyl-7-oxo-2,3-dihydro-7H-pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic acid; 6-Carboxy-9,10-difluoro-2,3-dihydro-2-methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine; 9,10-Difluoro-2-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid; Levofloxacin Intermediate; Levofloxacin Impurity; Levofloxacin Related Compound; Difluoro Oxazine Carboxylic Acid Derivative
EINECS	Contact for details

Quality Control

Our 9,10-Difluoro-2,3-Dihydro-2-Methyl-7-Oxo-7H-Pyrido[1,2,3-De]-1,4-Benzoxazine-6-Carboxylic Acid is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, NMR, and MS, to ensure high purity and consistent identity suitable for pharmaceutical applications. Certificates of Analysis (COA) detailing all specifications are provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated place at a controlled room temperature (15-25°C). Due to its hygroscopic (moisture-sensitive) nature, the container must be kept tightly sealed after opening to prevent degradation from atmospheric moisture.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%
Water Content (KF)	≤ 1.0%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.