Description

Botulinum Toxin G is a potent neurotoxin produced by the bacterium *Clostridium botulinum*. This specific serotype is a critical tool in advanced biomedical research, particularly for studying synaptic transmission and neuronal function. It is primarily utilized by research institutions, pharmaceutical R&D departments, and biotechnology companies investigating neuromuscular disorders and developing novel therapeutic agents.

Application

• Neuroscience Research: Fundamental studies on the mechanisms of neurotransmitter release, synaptic vesicle fusion, and neuronal exocytosis.
• Pharmacology & Toxicology: Investigation of botulinum toxin mechanisms of action and evaluation of potential antidotes or inhibitors.
• Biomedical Model Development: Creation of experimental models for neuromuscular diseases to test therapeutic interventions.
• Biochemical Reagent: Used as a highly specific protease to cleave target SNARE proteins (e.g., VAMP/synaptobrevin) in cell biology and biochemistry assays.
• Therapeutic R&D: Research into the potential development of new serotype-based therapeutic applications, although clinical use is currently dominated by serotypes A and B.

Basic Information

Product Name	Botulinum Toxin G
CAS No.	107231-16-3
Molecular Formula	Contact for details
Molecular Weight	~150 kDa (Holotoxin Complex)
Synonyms	Botulinum Neurotoxin Type G; BoNT/G; Clostridium botulinum Toxin Type G; BotG; Botulinum Toxin Serotype G; Botulinum Hemagglutinin Complex Type G; C. botulinum Toxin G
EINECS	Contact for details

Quality Control

Our Botulinum Toxin G is produced and handled under stringent quality management protocols suitable for research use. Each batch is subjected to rigorous analytical testing to ensure identity, purity, and consistent biological activity. A comprehensive Certificate of Analysis (COA) detailing specific purity, potency (LD50), and endotoxin levels is provided to support your research integrity and reproducibility.

Storage

Preserve in a tightly closed container, protected from light. For long-term stability, store frozen at -20°C or below. This product is hygroscopic (moisture-sensitive). Avoid repeated freeze-thaw cycles. Aliquot into single-use vials upon receipt if possible.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder or crystalline solid
Identification (SDS-PAGE / Immunoassay)	Conforms
Purity (HPLC)	≥ 95%
Specific Activity (Mouse LD50)	≥ 1 x 107 LD50 units/mg
Endotoxin Level (LAL)	< 10 EU/mg
Protein Content (Bradford/BCA)	Reported on COA
Solubility	Soluble in appropriate buffered saline solutions

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.