Description

Alanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Leucyl-2-Methyl- CAS NO 107076-69-7 is a specialized, protected amino acid derivative used as a critical building block in solid-phase peptide synthesis (SPPS). This compound matters because it provides the precise stereochemistry and side-chain protection required for the efficient and high-fidelity construction of complex peptides and proteins. It is essential for researchers and manufacturers in the pharmaceutical, biotechnology, and life science sectors who are developing novel therapeutic peptides, diagnostic agents, and biochemical tools.

Application

• Solid-Phase Peptide Synthesis (SPPS): A key intermediate for the sequential addition of amino acids in automated peptide synthesizers.
• Pharmaceutical Research: Used in the R&D of novel peptide-based drugs, including hormone analogs, antimicrobial peptides, and targeted therapeutics.
• Bioconjugation: Serves as a modified amino acid for creating site-specifically labeled peptides for imaging, diagnostics, or drug delivery systems.
• Combinatorial Chemistry: Employed in libraries for high-throughput screening to discover new bioactive peptide leads.
• Academic & Institutional Research: Fundamental reagent for studying protein structure-function relationships, enzyme substrates, and signal transduction pathways.

Basic Information

Product Name	Alanine, n-[(9H-Fluoren-9-Ylmethoxy)Carbonyl]-L-Leucyl-2-Methyl-
CAS No.	107076-69-7
Molecular Formula	C30H38N2O6
Molecular Weight	522.64 g/mol
Synonyms	Fmoc-L-Leucyl-2-methyl-L-alanine; Fmoc-Leu-2-MeAla-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-leucyl-2-methyl-L-alanine; Fmoc-Leu-(2-Me)Ala-OH; (2S)-2-[[(2S)-2-[[(9H-Fluoren-9-ylmethoxy)carbonyl]amino]-4-methylpentanoyl]amino]-2-methylpropanoic acid; Fmoc-Leu-α-MeAla-OH; Protected dipeptide Fmoc-Leu-2-MeAla; Fmoc-L-Leu-2-methyl-L-Ala
EINECS	Contact for details

Quality Control

Our Fmoc-protected dipeptide is manufactured under strict quality systems to ensure batch-to-batch consistency and high purity, essential for sensitive peptide synthesis. Each lot is accompanied by a comprehensive Certificate of Analysis (COA) detailing purity (typically ≥95% by HPLC), chiral purity, and identity confirmation. We support research and cGMP manufacturing with traceable documentation and stability data upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at 2-8°C in a dry environment. This product is hygroscopic (moisture-sensitive); allow the sealed container to reach room temperature before opening to prevent condensation and moisture ingress.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 95.0%
Chiral Purity	≥ 99.0% (L-configuration)
Water Content (KF)	≤ 1.0%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.