Description

Mastoparan, Des-Ile(1)-Des-Asn(2)- CAS NO 107048-32-8 is a synthetic, truncated analog of the natural mastoparan peptide, designed for enhanced stability and specific biological activity. This compound is a valuable research-grade biochemical tool, primarily utilized for its potent G-protein activating and mast cell degranulating properties. It is essential for researchers in pharmacology, cell biology, and immunology studying signal transduction pathways, cellular secretion, and inflammatory responses.

Application

• Biochemical Research: A critical tool for studying G-protein coupled receptor (GPCR) signaling and the activation of heterotrimeric G proteins (Gi, Go).
• Cell Biology Studies: Used to investigate mast cell degranulation, histamine release, and other secretory processes in immune cells.
• Pharmacology Screening: Serves as a reference agonist or positive control in assays designed to discover or characterize inhibitors of mast cell activation.
• Neuroscience Research: Applied in studies of neuronal exocytosis and the modulation of ion channels via G-protein pathways.
• Inflammation Models: Utilized to induce controlled inflammatory responses in in vitro cellular models for anti-inflammatory drug testing.
• Peptide Structure-Activity Relationship (SAR) Studies: The truncated sequence provides a basis for designing and evaluating novel peptide analogs with modified activity profiles.

Basic Information

Product Name	Mastoparan, Des-Ile(1)-Des-Asn(2)- CAS NO 107048-32-8
CAS No.	107048-32-8
Molecular Formula	C70H113N21O19
Molecular Weight	1568.8 g/mol
Synonyms	Mastoparan (7-14); Mastoparan Fragment 7-14; [Des-Ile1, Des-Asn2]-Mastoparan; INLKALAALAKKIL-NH2 (acetate salt); G-protein Activating Peptide; Mast Cell Degranulating Peptide Analog; Mastoparan Truncated Analog; LKALAALAKKIL-amide
EINECS	Contact for details

Quality Control

Our research-grade Mastoparan, Des-Ile(1)-Des-Asn(2)- is produced under stringent conditions to ensure batch-to-batch consistency and high biological activity. Each lot undergoes comprehensive analytical characterization, including HPLC for purity verification and mass spectrometry (MS) for identity confirmation. Certificates of Analysis (COA) detailing purity, peptide content, and analytical data are available upon request.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake. For long-term storage, keep desiccated at -20°C.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC & MS)	Conforms to reference standard
Purity (HPLC)	≥ 95%
Peptide Content	≥ 80% (by weight)
Single Impurity (HPLC)	≤ 1.0%
Water Content (KF)	≤ 5.0%
Acetate Content (HPLC/IC)	5 - 15 molecules per peptide

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.