Description

Angiotensin I, Sar(1)-Ile(5)-α-Me-Ala(7)- is a synthetic, modified peptide analog of the endogenous hormone Angiotensin I, designed for enhanced stability and specific receptor interaction. This compound is a critical research-grade biochemical tool for studying the renin-angiotensin system (RAS), a key regulator of blood pressure and fluid balance. It is primarily utilized by pharmaceutical R&D laboratories, academic research institutions, and biotechnology companies focused on cardiovascular disease, hypertension research, and novel drug discovery.

Application

• Biochemical Research: A key reference standard and tool for in vitro studies of the renin-angiotensin-aldosterone system (RAAS) pathway and enzyme kinetics.
• Pharmacological Studies: Used to investigate receptor binding affinities, signal transduction mechanisms, and the effects of angiotensin-converting enzyme (ACE) inhibitors.
• Drug Discovery & Development: Serves as a precursor or intermediate in the synthesis and screening of novel cardiovascular therapeutics targeting hypertension and heart failure.
• Diagnostic Assay Development: Employed as a calibrated standard in the development and validation of immunoassays (e.g., ELISA) for angiotensin peptide quantification.
• Academic & Clinical Research: Facilitates fundamental research into vascular biology, renal physiology, and the pathophysiology of cardiovascular and renal diseases.

Basic Information

Product Name	Angiotensin I, Sar(1)-Ile(5)-α-Me-Ala(7)-
CAS No.	107016-75-1
Molecular Formula	C49H71N13O11
Molecular Weight	1002.2 g/mol
Synonyms	[Sar1,Ile5,(α-Me)Ala7]-Angiotensin I; Sar1-Ile5-(α-methyl-Ala7)-Angiotensin I; Angiotensin I (1-10), 1-sarcosyl-5-isoleucyl-7-(α-methylalanyl)-; Modified Angiotensin I; Angiotensin I Analog; Sar1, Ile5, (α-Me)Ala7 Angiotensin I
EINECS	Contact for details

Quality Control

Our Angiotensin I, Sar(1)-Ile(5)-α-Me-Ala(7)- is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity suitable for research applications. Each lot is characterized by advanced analytical techniques including HPLC, MS, and NMR. A comprehensive Certificate of Analysis (COA) detailing purity, identity, and impurity profiles is provided with every shipment to support your research integrity and compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. This product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature in a desiccator before opening to minimize moisture uptake.

Specification

Item	Specification
Appearance	White to off-white lyophilized powder
Identification (HPLC)	Conforms to reference standard
Identification (MS)	Conforms to theoretical mass
Purity (HPLC)	≥ 95.0%
Water Content (KF)	≤ 5.0%
Peptide Content	≥ 80.0%
Solubility	Soluble in water, DMSO, acetic acid

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.