Description

9-Fluoroenylmethoxycarbonylpyroglutamate (CAS NO 106982-77-8) is a specialized, high-purity chemical building block designed for advanced synthetic applications. This compound is critical for researchers and manufacturers requiring precise molecular control in complex organic syntheses. It is primarily utilized in the pharmaceutical and biotechnology sectors for the development of novel peptide-based therapeutics and active pharmaceutical ingredients (APIs).

Application

• Peptide Synthesis: Serves as a key protected intermediate in solid-phase and solution-phase peptide synthesis (SPPS).
• Pharmaceutical Research: Used in the research and development of new drug candidates, particularly those targeting neurological and metabolic disorders.
• API Manufacturing: Acts as a crucial building block in the multi-step synthesis of complex active pharmaceutical ingredients.
• Bioconjugation: Employed in the development of peptide-drug conjugates and other targeted biopharmaceuticals.
• Chemical Biology: Utilized as a tool compound for studying enzyme mechanisms and protein-protein interactions.
• Process Development: Supports scale-up and optimization of synthetic routes in pilot plant and commercial manufacturing.

Basic Information

Product Name	9-Fluoroenylmethoxycarbonylpyroglutamate
CAS No.	106982-77-8
Molecular Formula	C₂₀H₁₅FNO₅
Molecular Weight	368.34 g/mol
Synonyms	Fmoc-Pyr-OH; Fmoc-L-Pyroglutamic acid; Fmoc-L-Pyr-OH; N-[(9H-Fluoren-9-ylmethoxy)carbonyl]-L-pyroglutamic acid; (S)-5-Oxo-1-((((9H-fluoren-9-yl)methoxy)carbonyl)amino)pyrrolidine-2-carboxylic acid; N-α-Fmoc-L-pyroglutamic acid; Fmoc-L-pyroglutamate; Fmoc-Pyroglutamic Acid
EINECS	Contact for details

Quality Control

Our 9-Fluoroenylmethoxycarbonylpyroglutamate is manufactured under strict quality management systems to ensure batch-to-batch consistency and high purity. Each lot is subjected to comprehensive analytical testing, including HPLC, NMR, and mass spectrometry, to confirm identity, purity, and the absence of critical impurities. A Certificate of Analysis (COA) detailing all test results is provided with every shipment to support your quality assurance and regulatory compliance needs.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). Due to its hygroscopic nature, the container must be kept tightly sealed in a dry environment to prevent moisture absorption, which can affect stability and performance. For long-term storage, consider using desiccants.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Conforms to reference standard
Assay (HPLC)	≥98.0%
Optical Rotation [α]²⁰D	-30.0° to -35.0° (c=1 in DMF)
Water Content (KF)	≤0.5%
Heavy Metals	≤10 ppm
Residual Solvents (GC)	Meets ICH Q3C guidelines

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.