Description

2-Amino-3-(Trifluoromethyl)Phenol is a versatile trifluoromethylated aniline derivative that serves as a critical building block in advanced organic synthesis. Its unique structure, featuring both an amino and a phenolic hydroxyl group adjacent to a strong electron-withdrawing trifluoromethyl group, makes it invaluable for creating compounds with tailored electronic and steric properties. This high-purity intermediate is primarily sought by research institutions and manufacturers in the pharmaceutical and agrochemical sectors for developing new active ingredients.

Application

• Pharmaceutical Intermediate: A key synthon for the development of novel active pharmaceutical ingredients (APIs), particularly in medicinal chemistry programs targeting CNS and anti-inflammatory agents.
• Agrochemical Synthesis: Used in the research and production of advanced herbicides and pesticides, where the trifluoromethyl group enhances biological activity and metabolic stability.
• Ligand and Catalyst Preparation: Serves as a precursor for chelating ligands in asymmetric catalysis and metal-organic frameworks (MOFs).
• Functional Material Development: Employed in the synthesis of specialty polymers, dyes, and electronic materials that require fluorinated aromatic components.
• Organic Synthesis Building Block: Utilized in cross-coupling reactions, such as Buchwald-Hartwig amination, to introduce the aminophenol moiety into complex molecular architectures.

Basic Information

Product Name	2-Amino-3-(Trifluoromethyl)Phenol
CAS No.	106877-48-9
Molecular Formula	C7H6F3NO
Molecular Weight	177.12 g/mol
Synonyms	3-Trifluoromethyl-2-aminophenol; 2-Amino-α,α,α-trifluoro-m-cresol; 2-Amino-3-(trifluoromethyl)benzenol; 3-Amino-6-(trifluoromethyl)phenol; 2-Hydroxy-6-(trifluoromethyl)aniline; Benzenol, 2-amino-3-(trifluoromethyl)-; 2-Amino-3-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 2-Amino-3-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for research and industrial synthesis. A comprehensive Certificate of Analysis (COA) detailing all specifications is provided with every shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated area at a controlled room temperature (15-25°C). Keep away from strong oxidizing agents, strong acids, and strong bases. Due to its phenolic and aniline nature, it is recommended to handle and store under an inert atmosphere for long-term stability.

Specification

Item	Specification
Appearance	Off-white to light yellow crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.