Description

3-Methoxy-4-(Trifluoromethyl)Phenol is a versatile fluorinated phenolic compound that serves as a key building block in advanced organic synthesis. Its unique structure, featuring both a methoxy group and a trifluoromethyl substituent on the aromatic ring, provides valuable electronic and steric properties for modifying molecular characteristics. This high-purity intermediate is essential for researchers and manufacturers in the pharmaceutical and agrochemical sectors seeking to develop novel active ingredients with enhanced metabolic stability and bioavailability.

Application

• Pharmaceutical Intermediate: A critical precursor in the synthesis of active pharmaceutical ingredients (APIs), particularly for candidates targeting central nervous system (CNS) disorders, inflammation, and metabolic diseases.
• Agrochemical Synthesis: Used in the development of next-generation herbicides, fungicides, and insecticides, where the trifluoromethyl group can improve lipophilicity and biological activity.
• Liquid Crystal Materials: Serves as a core component in the production of fluorinated liquid crystals for advanced display technologies.
• Polymer Modification: Acts as a monomer or additive to introduce fluorine into polymer backbones, enhancing chemical resistance, thermal stability, and surface properties of specialty plastics and coatings.
• Organic Electronic Materials: Employed in the research and development of organic semiconductors and charge-transport materials for OLEDs and photovoltaic cells.
• Chemical Research & Development: A valuable reagent for medicinal chemistry and process chemistry R&D, enabling structure-activity relationship (SAR) studies and route scouting.

Basic Information

Product Name	3-Methoxy-4-(Trifluoromethyl)Phenol
CAS No.	106877-41-2
Molecular Formula	C8H7F3O2
Molecular Weight	192.14 g/mol
Synonyms	4-(Trifluoromethyl)guaiacol; 3-Hydroxy-4-methoxybenzotrifluoride; 4-Methoxy-3-(trifluoromethyl)phenol; 2-Methoxy-5-(trifluoromethyl)phenol; 3-Methoxy-α,α,α-trifluoro-p-cresol; 5-(Trifluoromethyl)guaiacol; Phenol, 3-methoxy-4-(trifluoromethyl)-; 3-Methoxy-4-trifluoromethylphenol
EINECS	Contact for details

Quality Control

Our 3-Methoxy-4-(Trifluoromethyl)Phenol is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC, GC, NMR, and IR spectroscopy, to ensure high chemical purity and consistent lot-to-lot performance. We provide comprehensive Certificates of Analysis (COA) with each shipment, detailing all specification parameters. Our quality commitment aligns with cGMP principles where applicable, supporting our customers' regulatory and research requirements.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, well-ventilated place at room temperature (15-25°C). Keep away from strong oxidizing agents, strong bases, and heat sources. The compound may be light-sensitive; prolonged exposure to light should be avoided.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 10 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.