Description

Ethyl 6-Methyl-4-(3-Nitrophenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is a high-purity, advanced pharmaceutical intermediate belonging to the tetrahydropyrimidine class of heterocyclic compounds. This compound matters as a critical building block in the synthesis of complex active pharmaceutical ingredients (APIs), offering a defined structural core for further chemical elaboration. It is primarily needed by research institutions and manufacturers in the pharmaceutical and agrochemical industries for the development of new therapeutic agents and specialty chemicals.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of novel drug candidates, particularly those targeting central nervous system (CNS) disorders, cardiovascular diseases, and anti-inflammatory applications.
• Agrochemical Research: Serves as a versatile scaffold for developing new herbicides, fungicides, and plant growth regulators with specific biological activity.
• Chemical Synthesis Building Block: Used in academic and industrial R&D for constructing complex heterocyclic libraries for high-throughput screening and medicinal chemistry programs.
• Material Science Applications: Potential use as an intermediate for specialty polymers and organic electronic materials due to its conjugated nitro-aromatic and thiocarbonyl functional groups.

Basic Information

Product Name	Ethyl 6-Methyl-4-(3-Nitrophenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate
CAS No.	106720-50-7
Molecular Formula	C₁₄H₁₅N₃O₄S
Molecular Weight	321.35 g/mol
Synonyms	Ethyl 6-methyl-4-(3-nitrophenyl)-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylate; 4-(3-Nitrophenyl)-6-methyl-2-thioxo-1,2,3,4-tetrahydropyrimidine-5-carboxylic acid ethyl ester; 5-Carbethoxy-6-methyl-4-(3-nitrophenyl)-3,4-dihydro-2(1H)-pyrimidinethione; 1,2,3,4-Tetrahydropyrimidine-5-carboxylic acid, 6-methyl-4-(3-nitrophenyl)-2-thioxo-, ethyl ester; DHPM derivative; Biginelli reaction product; 3-Nitrophenyl DHPM derivative.
EINECS	Contact for details

Quality Control

Our Ethyl 6-Methyl-4-(3-Nitrophenyl)-2-Thioxo-1,2,3,4-Tetrahydropyrimidine-5-Carboxylate is manufactured under strict quality management systems. Every batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation via FT-IR and NMR spectroscopy, to ensure it meets the high standards required for pharmaceutical R&D. A comprehensive Certificate of Analysis (COA) detailing purity, impurities, and physical characteristics is provided with each shipment to guarantee traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at a controlled room temperature (15-25°C). Keep away from heat, open flames, and incompatible materials. The container should be kept tightly sealed to protect this light-sensitive compound from degradation.

Specification

Item	Specification
Appearance	Yellow to light brown crystalline powder
Identification (IR)	Conforms to structure
Purity (HPLC)	≥ 98.0%
Melting Point	Contact for details
Loss on Drying	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.