Description

H-Ser-Otbu · Hcl CAS NO 106402-41-9 is a protected serine derivative, specifically the hydrochloride salt of O-tert-butyl-L-serine. This compound serves as a critical chiral building block and intermediate in advanced organic synthesis, valued for its role in introducing the serine moiety while protecting the hydroxyl group. It is primarily utilized by research institutions and manufacturers in the pharmaceutical, biotechnology, and peptide synthesis industries for developing novel therapeutic agents and biochemical tools.

Application

• Pharmaceutical Intermediate: A key precursor in the synthesis of complex drug molecules and active pharmaceutical ingredients (APIs).
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate protected serine residues into peptide chains.
• Bioconjugation & Linker Chemistry: Employed in the design and construction of antibody-drug conjugates (ADCs) and other bioconjugates.
• Chemical Biology Research: Serves as a building block for creating probes, inhibitors, and other tools to study biological processes.
• Agrochemical Synthesis: Can be utilized as an intermediate in the production of certain specialty agrochemicals.
• Material Science: Potential use in the synthesis of functional polymers and advanced materials.

Basic Information

Product Name	H-Ser-Otbu · Hcl
CAS No.	106402-41-9
Molecular Formula	C7H16ClNO3
Molecular Weight	197.66 g/mol
Synonyms	O-tert-Butyl-L-serine hydrochloride; (S)-2-Amino-3-(tert-butoxy)propanoic acid hydrochloride; H-Ser(tBu)-OH · HCl; L-Serine, O-(1,1-dimethylethyl)-, hydrochloride (1:1); Ser-OtBu hydrochloride; Boc-Ser(tBu)-OH (related); Fmoc-Ser(tBu)-OH (related); Protected Serine HCl
EINECS	Contact for details

Quality Control

Our H-Ser-Otbu · Hcl is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity, chiral analysis, and identity confirmation (IR, NMR) to ensure it meets high-purity standards suitable for research and cGMP manufacturing. Certificates of Analysis (COA) with detailed specifications are provided for every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity. For long-term storage, consider desiccants and a nitrogen atmosphere.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥98.0%
Chiral Purity (HPLC)	≥99.0%
Water Content (KF)	≤1.0%
Residue on Ignition	≤0.1%
Heavy Metals	≤10 ppm
Solubility	Soluble in water, DMF, DMSO; slightly soluble in methanol

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.