Description

γ-Methyl-L-Leucine CAS NO 106247-35-2 is a non-proteinogenic amino acid derivative characterized by its unique branched-chain structure with a γ-methyl group. This compound is of significant value in advanced pharmaceutical research and peptide synthesis, where it serves as a crucial building block for modifying peptide properties and creating novel bioactive molecules. It is primarily needed by research institutions, pharmaceutical development companies, and fine chemical manufacturers focused on metabolic studies, drug discovery, and the production of specialized peptides and peptidomimetics.

Application

• Pharmaceutical Intermediate: A key chiral building block in the synthesis of novel active pharmaceutical ingredients (APIs) and therapeutic peptides.
• Peptide Synthesis: Used in solid-phase and solution-phase peptide synthesis to incorporate structural modifications that influence peptide stability, bioavailability, and receptor binding affinity.
• Metabolic Research: Serves as a tool compound in biochemical and metabolic pathway studies, particularly those investigating amino acid metabolism and related disorders.
• Proteomics & Biochemistry: Employed in the design and study of enzyme inhibitors, receptor ligands, and other biologically active molecules.
• Fine Chemical Synthesis: A versatile intermediate for synthesizing more complex chiral molecules used in agrochemicals and other specialty chemicals.

Basic Information

Product Name	γ-Methyl-L-Leucine
CAS No.	106247-35-2
Molecular Formula	C7H15NO2
Molecular Weight	145.20 g/mol
Synonyms	L-γ-Methylleucine; (2S)-2-Amino-4-methylpentanoic acid; (S)-2-Amino-4-methylpentanoic acid; γ-Methyl-L-leucine; L-γ-Methylleucine; 4-Methyl-L-norvaline; (S)-γ-Methylleucine; L-2-Amino-4-methylpentanoic acid
EINECS	Contact for details

Quality Control

Our γ-Methyl-L-Leucine is produced under strict quality management systems. Each batch undergoes rigorous analytical testing, including chiral purity verification and impurity profiling, to ensure it meets the high standards required for research and synthesis applications. A comprehensive Certificate of Analysis (COA) detailing identity, purity (by HPLC), specific rotation, and residual solvent levels is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry, and well-ventilated area at controlled room temperature (15-25°C). This product is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and purity.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Assay (HPLC)	≥ 98.0%
Chiral Purity (HPLC)	≥ 99.0%
Specific Rotation	Contact for details
Loss on Drying	≤ 1.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.