Description

1-(Phenoxycarbonyloxymethyl)-5-Fluorouracil is a chemically modified prodrug derivative of the established antimetabolite 5-fluorouracil (5-FU). This compound is designed for enhanced stability and targeted delivery, offering a crucial advantage in pharmaceutical research and development. It serves as a key synthetic intermediate and a promising candidate for researchers in oncology and medicinal chemistry, particularly for developing novel chemotherapeutic agents and studying drug metabolism.

Application

• Pharmaceutical Intermediate: A critical building block in the synthesis of advanced, targeted chemotherapeutic prodrugs.
• Oncology Research: Used in preclinical studies to investigate new mechanisms for delivering 5-fluorouracil to tumor sites with improved selectivity.
• Prodrug Development: Serves as a model compound for designing and evaluating novel prodrug strategies aimed at improving pharmacokinetics and reducing systemic toxicity.
• Biochemical Research: Employed in studies of enzyme-triggered drug release mechanisms, particularly those involving esterases.
• API Synthesis: Utilized in the controlled synthesis of active pharmaceutical ingredients (APIs) for experimental cancer therapies.

Basic Information

Product Name	1-(Phenoxycarbonyloxymethyl)-5-Fluorouracil
CAS No.	106219-33-4
Molecular Formula	C13H11FN2O5
Molecular Weight	294.24 g/mol
Synonyms	5-Fluorouracil-1-ylmethyl phenyl carbonate; 1-[[(Phenoxycarbonyl)oxy]methyl]-5-fluorouracil; 5-FU Prodrug Derivative; 1-Phenoxycarbonyloxymethyl-5-fluorouracil; 1-Hydroxymethyl-5-fluorouracil phenyl carbonate; NSC 77690; Ftorafur related compound; 5-Fluorouracil-1-carboxymethyl phenyl ester
EINECS	Contact for details

Quality Control

Our 1-(Phenoxycarbonyloxymethyl)-5-Fluorouracil is manufactured under strict quality management systems. Each batch undergoes comprehensive analytical testing, including HPLC for purity and identity confirmation via IR and NMR spectroscopy, to ensure it meets the high standards required for research and development. A Certificate of Analysis (COA) detailing all specifications is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (typically 15-25°C). This material is moisture-sensitive (hygroscopic) and should be handled under anhydrous conditions to maintain stability.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to structure
Identification (HPLC)	Retention time matches reference standard
Purity (HPLC)	≥ 98.0%
Water Content (KF)	≤ 0.5%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.