Description

Senktide CAS NO 106128-89-6 is a potent and selective neurokinin-1 (NK1) receptor antagonist peptide. This compound matters as a critical research tool for investigating the physiological roles of substance P and the NK1 receptor pathway in pain transmission, inflammation, and central nervous system disorders. It is primarily needed by pharmaceutical R&D teams, academic researchers, and biotechnology companies focused on neuroscience, analgesia, and neuropharmacology.

Application

• Neuroscience Research: A key pharmacological tool for studying the function of substance P and NK1 receptors in the brain and spinal cord.
• Pain Mechanism Studies: Used in preclinical models to investigate the role of the NK1 receptor in nociception and the development of novel analgesic targets.
• Inflammatory Response Analysis: Employed to elucidate the connection between neurogenic inflammation and NK1 receptor activation.
• Behavioral Pharmacology: Facilitates research into the influence of the NK1 system on depression, anxiety, stress, and emesis.
• Drug Discovery & Development: Serves as a reference standard and lead compound in the development of new NK1 receptor antagonists for therapeutic applications.
• Biochemical Assays: Used in receptor binding studies and functional assays (e.g., calcium flux) to characterize compound activity and receptor kinetics.

Basic Information

Product Name	Senktide
CAS No.	106128-89-6
Molecular Formula	C58H84N16O13S
Molecular Weight	1221.4 g/mol
Synonyms	Succinyl-[Asp6,N-Me-Phe8]SP(6-11); [pGlu6,Pro9]SP(6-11) trifluoroacetate salt; Senktide trifluoroacetate; Neurokinin 1 Receptor Agonist; Selective NK1 Receptor Agonist; SP agonist; (Arg-Pro-Lys-Pro-Gln-Gln-Phe-Phe-Gly-Leu-Met-NH2) derivative
EINECS	Contact for details

Quality Control

Our Senktide is manufactured under strict quality management systems. Each batch undergoes rigorous analytical testing, including HPLC for purity and identity confirmation, to ensure it meets the high standards required for research applications. A comprehensive Certificate of Analysis (COA) detailing purity, peptide content, and analytical data is provided with every shipment.

Storage

Preserve in a tightly closed container, protected from light. Store at -20°C or below in a dry environment. The product is hygroscopic (moisture-sensitive). Allow the vial to equilibrate to room temperature before opening to minimize moisture absorption.

Specification

Item	Specification
Appearance	White to off-white powder
Identification (HPLC/MS)	Conforms to structure
Purity (HPLC)	≥95%
Peptide Content	≥80%
Water Content (KF)	≤8.0%
Solubility	Soluble in water, DMSO

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.