Description

Clinafloxacin Hydrochloride is a synthetic fluoroquinolone antibiotic known for its potent broad-spectrum antibacterial activity. This compound is a critical active pharmaceutical ingredient (API) and a valuable reference standard for research and development. It is primarily utilized by pharmaceutical manufacturers, contract research organizations (CROs), and analytical laboratories. The product is supplied under stringent quality control to ensure reliability for both commercial production and advanced scientific studies.

Application

• Pharmaceutical API: Serves as the active ingredient in the formulation of antibacterial medications.
• Reference Standard: Used for quality control, method validation, and calibration in analytical chemistry (HPLC, LC-MS).
• Biomedical Research: Employed in in vitro and in vivo studies to investigate mechanisms of action and resistance against Gram-positive and Gram-negative bacteria.
• Antimicrobial Susceptibility Testing (AST): A key component in preparing discs or solutions for determining bacterial sensitivity.
• Intermediate for Synthesis: Used in the chemical synthesis of novel quinolone derivatives and prodrugs.
• Veterinary Medicine: Potential application in developing treatments for bacterial infections in animals.

Basic Information

Product Name	Clinafloxacin Hydrochloride
CAS No.	105956-99-8
Molecular Formula	C17H17ClF2N4O3 • HCl
Molecular Weight	441.70 g/mol
Synonyms	Clinafloxacin HCl; PD 127391; AM-1091; (R,S)-7-(3-Amino-1-pyrrolidinyl)-8-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4-oxo-3-quinolinecarboxylic acid hydrochloride; CI-960 hydrochloride; (+)-Clinafloxacin hydrochloride; 1-Cyclopropyl-6,8-difluoro-1,4-dihydro-7-(3S,4S)-3-[(1-iminoethyl)amino]-4-methyl-1-pyrrolidinyl-4-oxo-3-quinolinecarboxylic acid hydrochloride (mixture of isomers)
EINECS	Contact for details

Quality Control

Our Clinafloxacin Hydrochloride is manufactured and tested to meet high-purity standards suitable for pharmaceutical applications. Each batch undergoes comprehensive analytical testing, including identification, assay, and impurity profiling via HPLC and other pharmacopeial methods. A Certificate of Analysis (COA) is provided with each shipment, detailing all test results against established specifications. We adhere to a cGMP-compliant quality management system to ensure traceability and consistency.

Storage

Preserve in a tightly closed container, protected from light. Store in a cool, dry place at a controlled room temperature (15-25°C). This material is hygroscopic (moisture-sensitive) and must be kept under dry, inert conditions to maintain stability and potency.

Specification

Item	Specification
Appearance	White to off-white crystalline powder
Identification (IR)	Conforms to reference spectrum
Identification (HPLC)	Retention time matches reference standard
Assay (HPLC)	≥ 98.0% (on anhydrous basis)
Water Content (KF)	≤ 2.0%
Residue on Ignition	≤ 0.1%
Heavy Metals	≤ 20 ppm
Related Substances (HPLC)	Total impurities ≤ 2.0% Any single impurity ≤ 0.5%

Note: Specifications can be tailored. Please contact us for the detailed technical data sheet of a specific grade.